Gene A, a gene increased by mutant KRAS, is a potentially druggable target for lung adenocarcinoma

被引:0
|
作者
Umeda, Kanna [1 ]
Kawabe, Nozomi [1 ]
Muraki, Nao [1 ]
Komeda, Kazuki [2 ]
Ohashi, Ayano [1 ]
Katsuda, Masahito [1 ]
Tomatsu, Aya [1 ]
Yoshida, Mikina [1 ]
Minna, John [3 ,4 ]
Tanaka, Ichidai [2 ]
Morise, Masahiro [2 ]
Matsushima, Miyoko [1 ]
Kawabe, Tsutomu [1 ]
Sato, Mitsuo [1 ]
机构
[1] Nagoya Univ, Div Host Def Sci, Dept Integrated Hlth Sci, Grad Sch Med, Nagoya, Aichi, Japan
[2] Nagoya Univ, Dept Resp Med, Grad Sch Med, Nagoya, Aichi, Japan
[3] Univ Texas Southwestern Med Ctr Dallas, Hamon Ctr Therapeut Oncol Res, Dallas, TX 75390 USA
[4] Univ Texas Southwestern Med Ctr Dallas, Simmons Comprehens Canc Ctr, Dallas, TX 75390 USA
关键词
D O I
暂无
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
AP04-003
引用
收藏
页码:91 / 91
页数:1
相关论文
共 50 条
  • [31] Effect of mutant variants of the KRAS gene on PD-L1 expression and on the immune microenvironment and association with clinical outcome in lung adenocarcinoma patients
    Falk, Alexander T.
    Yazbeck, Nathalie
    Guibert, Nicolas
    Chamorey, Emmanuel
    Paquet, Agnes
    Ribeyre, Lydia
    Bence, Coraline
    Zahaf, Katia
    Leroy, Sylvie
    Marquette, Charles-Hugo
    Cohen, Charlotte
    Mograbi, Baharia
    Mazieres, Julien
    Hofman, Veronique
    Brest, Patrick
    Hofman, Paul
    Ilie, Marius
    LUNG CANCER, 2018, 121 : 70 - 75
  • [32] Increased mutant KRAS gene dosage drives pancreatic cancer progression: evidence for wild-type KRAS as a tumor suppressor?
    Kent, Oliver A.
    HEPATOBILIARY SURGERY AND NUTRITION, 2018, 7 (05) : 403 - 405
  • [33] A Deregulated HOX Gene Axis Confers an Epigenetic Vulnerability in KRAS-Mutant Lung Cancers
    Guerra, Stephanie L.
    Maertens, Ophelia
    Kuzmickas, Ryan
    De Raedt, Thomas
    Adeyemi, Richard O.
    Guild, Caroline J.
    Guillemette, Shawna
    Redig, Amanda J.
    Chambers, Emily S.
    Xu, Man
    Tiv, Hong
    Santagata, Sandro
    Janne, Pasi A.
    Elledge, Stephen J.
    Cichowski, Karen
    CANCER CELL, 2020, 37 (05) : 705 - +
  • [34] In Vivo Epigenetic CRISPR Screen Identifies Asf1a as an Immunotherapeutic Target in Kras-Mutant Lung Adenocarcinoma
    Li, Fei
    Huang, Qingyuan
    Luster, Troy A.
    Hu, Hai
    Zhang, Hua
    Ng, Wai-Lung
    Khodadadi-Jamayran, Alireza
    Wang, Wei
    Chen, Ting
    Deng, Jiehui
    Ranieri, Michela
    Fang, Zhaoyuan
    Pyon, Val
    Dowling, Catriona M.
    Bagdatlioglu, Ece
    Almonte, Christina
    Labbe, Kristen
    Silver, Heather
    Rabin, Alexandra R.
    Jani, Kandarp
    Tsirigos, Aristotelis
    Papagiannakopoulos, Thales
    Hammerman, Peter S.
    Velcheti, Vamsidhar
    Freeman, Gordon J.
    Qi, Jun
    Miller, George
    Wong, Kwok-Kin
    CANCER DISCOVERY, 2020, 10 (02) : 270 - 287
  • [35] Coexistence of two missense mutations in the KRAS gene in adenocarcinoma of the lung: a possible indicator of poor prognosis
    Spinelli, Manuela
    Du Parcq, Persephone
    Gupta, Nandita
    Khorashad, Jamshid
    Viola, Patrizia
    PATHOLOGICA, 2022, 114 (03) : 221 - 227
  • [36] Gene expression profiling of epidermal growth factor receptor/KRAS pathway activation in lung adenocarcinoma
    Shibata, Tatsuhiro
    Hanada, Satoko
    Kokubu, Akiko
    Matsuno, Yoshihiro
    Asamura, Hisao
    Ohta, Tsutomu
    Sakamoto, Michiie
    Hirohashi, Setsuo
    CANCER SCIENCE, 2007, 98 (07): : 985 - 991
  • [37] XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer
    Jimi Kim
    Elizabeth McMillan
    Hyun Seok Kim
    Niranjan Venkateswaran
    Gurbani Makkar
    Jaime Rodriguez-Canales
    Pamela Villalobos
    Jasper Edgar Neggers
    Saurabh Mendiratta
    Shuguang Wei
    Yosef Landesman
    William Senapedis
    Erkan Baloglu
    Chi-Wan B. Chow
    Robin E. Frink
    Boning Gao
    Michael Roth
    John D. Minna
    Dirk Daelemans
    Ignacio I. Wistuba
    Bruce A. Posner
    Pier Paolo Scaglioni
    Michael A. White
    Nature, 2016, 538 : 114 - 117
  • [38] XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer
    Kim, Jimi
    McMillan, Elizabeth
    Kim, Hyun Seok
    Venkateswaran, Niranjan
    Makkar, Gurbani
    Rodriguez-Canales, Jaime
    Villalobos, Pamela
    Neggers, Jasper Edgar
    Mendiratta, Saurabh
    Wei, Shuguang
    Landesman, Yosef
    Senapedis, William
    Baloglu, Erkan
    Chow, Chi-Wan B.
    Frink, Robin E.
    Gao, Boning
    Roth, Michael
    Minna, John D.
    Daelemans, Dirk
    Wistuba, Ignacio I.
    Posner, Bruce A.
    Scaglioni, Pier Paolo
    White, Michael A.
    NATURE, 2016, 538 (7623) : 114 - +
  • [39] ΔFOSB: A Potentially Druggable Master Orchestrator of Activity-Dependent Gene Expression
    Robison, Alfred J.
    Nestler, Eric J.
    ACS CHEMICAL NEUROSCIENCE, 2022, 13 (03): : 296 - 307
  • [40] Fatty Acid Synthase Is a Therapeutic Target in Mutant KRAS Lung Cancer
    Bartolacci, C.
    Padanad, M.
    Andreani, C.
    Melegari, M.
    Rindhe, S.
    George, K.
    Frankel, A.
    McDonald, J.
    Scaglioni, P. P.
    JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (08) : S1538 - S1538