Recently, hyperspectral image (HSI) mixed denoising methods based on nonlocal subspace representation (NSR) have achieved significant success. However, most of these methods focus on optimizing the denoiser for representation coefficient images (RCIs) without considering how to construct RCIs that better inherit the spatial structure of the clean HSI, thereby affecting subsequent denoising performance. Although existing works have constructed RCIs from the perspective of sparse principal component analysis (SPCA), the refinement of RCIs in mixed noise conditions still leaves much to be desired. To address the aforementioned challenges, in this paper, we reconstructed robust RCIs based on SPCA in mixed noise circumstances to better preserve the spatial structure of the clean HSI. Furthermore, we propose to utilize the robust RCIs as prior information and perform iterative denoising in the denoiser that incorporates low-rank approximation. Extensive experiments conducted on both simulated and real HSI datasets demonstrate that the proposed robust RCIs guidance and low-rank approximation method, denoted as RRGNLA, exhibits competitive performance in terms of mixed denoising accuracy and computational efficiency. For instance, on the Washington DC Mall (WDC) dataset in Case 3, the denoising quantitative metrics of the mean peak signal-to-noise ratio (MPSNR), mean structural similarity index (MSSIM), and spectral angle mean (SAM) are 36.06 dB, 0.963, and 3.449, respectively, with a running time of 35.24 s. On the Pavia University (PaU) dataset in Case 4, the denoising quantitative metrics of MPSNR, MSSIM, and SAM are 34.34 dB, 0.924, and 5.505, respectively, with a running time of 32.79 s.