Impact of COVID-19 infection on lung function and nutritional status amongst individuals with cystic fibrosis: A global cohort study

被引：0

作者：

Semenchuk, Julie ^{[1
]}

Naito, Yumi ^{[2
]}

Charman, Susan C. ^{[2
]}

Carr, Siobhan B. ^{[3
,4
]}

Cheng, Stephanie Y. ^{[5
]}

Marshall, Bruce C. ^{[6
]}

Faro, Albert ^{[6
]}

Elbert, Alexander ^{[6
]}

Gutierrez, Hector H. ^{[7
]}

Goss, Christopher H. ^{[8
]}

Karadag, Bulent ^{[9
]}

Burgel, Pierre-Regis ^{[10
,11
]}

Colombo, Carla ^{[12
]}

Salvatore, Marco ^{[13
,14
]}

Padoan, Rita ^{[15
]}

Daneau, Geraldine ^{[16
]}

Harutyunyan, Satenik ^{[17
]}

Kashirskaya, Nataliya ^{[18
]}

Kirwan, Laura ^{[19
]}

Middleton, Peter G. ^{[20
]}

Ruseckaite, Rasa ^{[21
]}

de Monestrol, Isabelle ^{[22
]}

Naehrlich, Lutz ^{[23
]}

Mondejar-Lopez, Pedro ^{[24
]}

Jung, Andreas ^{[25
]}

van Rens, Jacqui ^{[26
]}

Bakkeheim, Egil ^{[27
]}

Orenti, Annalisa ^{[28
]}

Ommen, Domenique Zomer-van ^{[29
]}

da Silva-Filho, Luiz Vicente R. F. ^{[30
]}

Fernandes, Flavia Fonseca ^{[31
,32
]}

Zampoli, Marco ^{[33
]}

Stephenson, Anne L. ^{[1
]}

机构：

[1] St Michaels Hosp, Dept Respirol, Toronto, ON, Canada

[2] UK Trust, London, England

[3] Royal Brompton & Harefield Hosp, Guys & St Thomass NHS Fdn Trust, London, England

[4] Imperial Coll, London, England

[5] Cyst Fibrosis Canada, Toronto, ON, Canada

[6] Cyst Fibrosis Fdn, Bethesda, MD USA

[7] Univ Alabama Birmingham, Div Pediat Pulm & Sleep Med, Birmingham, AL USA

[8] Univ Washington, Dept Med, Div Pulm Crit Care & Sleep Med, Med Ctr, Seattle, WA USA

[9] Marmara Univ, Fac Med, Div Pediat Pulmonol, Istanbul, Turkiye

[10] Cochin Hosp, APHP, Natl Reference CF Ctr & Resp Med, Paris, France

[11] Univ Paris Cite, Inst Cochin InsermU1016, Paris, France

[12] Univ Milan, Fdn IRCCS CaGranda Osped Maggiore Policlin, Milan, Italy

[13] Natl Ctr Rare Dis, Undiagnosed Rare Dis Interdept Unit, Rome, Italy

[14] Ist Super Sanita, Italian CF, Rome, Italy

[15] Italian Cyst Fibrosis Registry, Sci Board, Rome, Italy

[16] Yerevan Univ, Muratsan Hosp, CF Ctr, Yerevan, Armenia

[17] Belgian Cyst Fibrosis Registry, Dept epidemiol & publ Hlth, Hlth Serv Res, Sciensano, Belgium

[18] Moscow Reg Res & Clin Inst MONIKI, Res Ctr Med Genet, Moscow, Russia

[19] Univ Coll Dublin, Cyst Fibrosis Registry Ireland, Woodview House, Dublin, Ireland

[20] Westmead Hosp, Dept Resp & Sleep Med, Bronchiectasis & CF Serv, Sydney, Australia

[21] Monash Univ, Dept Publ Hlth & Prevent Med, Melbourne, Vic, Australia

[22] Karolinska Univ Hosp Huddinge, Karolinska Inst, Stockholm CF Ctr, Dept Pediat, Huddinge, Sweden

[23] Justus Liebig Univ Giessen, Dept Pediat, Giessen, Germany

[24] Hosp Clin Univ Virgen Arrixaca, Murcia, Spain

[25] Univ Childrens Hosp Zurich, Dept Pulmonol, Zurich, Switzerland

[26] Univ Hosp Leuven, Dept Paediat, Leuven, Belgium

[27] Oslo Univ Hosp, Natl Resource Ctr Cyst Fibrosis, Dept Paediat & Adolescent Med, Oslo, Norway

[28] Univ Milan, Dept Clin Sci & Community Hlth, Dipartimento Eccellenza 2023 2027, Lab Med Stat Biometry & Epidemiol G A Maccacaro, Milan, Italy

[29] Dutch CF Fdn NCFS, Baarn, Netherlands

[30] Inst Crianca & Adolescente HCFMUSP, Sao Paulo, Brazil

[31] Univ Fed Catalao, Med Dept, Catalao, Brazil

[32] Hosp Base Dist Fed, Brasilia, Brazil

[33] Univ Cape Town, Red Cross War Mem Childrens Hosp, Dept Paediat & Child Hlth, Cape Town, South Africa

来源：

JOURNAL OF CYSTIC FIBROSIS | 2024年 / 23卷 / 05期

关键词：

COVID-19; Coronavirus; Cystic fibrosis; SARS-COV-2; INFECTION; PEOPLE; CHILDREN;

D O I：

10.1016/j.jcf.2024.07.019

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background Factors associated with severe COVID-19 infection have been identified; however, the impact of infection on longer-term outcomes is unclear. The objective of this study was to examine the impact of COVID-19 infection on the trajectory of lung function and nutritional status in people with cystic fibrosis (pwCF). Methods This is a retrospective global cohort study of pwCF who had confirmed COVID-19 infection diagnosed between January 1, 2020 and December 31, 2021. Forced expiratory volume in one second percent predicted (ppFEV(1)) and body mass index (BMI) twelve months prior to and following a diagnosis of COVID-19 were recorded. Change in mean ppFEV(1) and BMI were compared using a t-test. A linear mixed-effects model was used to estimate change over time and to compare the rate of change before and after infection. Results A total of 6,500 cases of COVID-19 in pwCF from 33 countries were included for analysis. The mean difference in ppFEV(1) pre- and post-infection was 1.4 %, (95 % CI 1.1, 1.7). In those not on modulators, the difference in rate of change pre- and post-infection was 1.34 %, (95 % CI -0.88, 3.56) per year (p = 0.24) and -0.74 % (-1.89, 0.41) per year (p = 0.21) for those on elexacaftor/tezacaftor/ivacaftor. No clinically significant change was noted in BMI or BMI percentile before and after COVID-19 infection. Conclusions No clinically meaningful impact on lung function and BMI trajectory in the year following infection with COVID-19 was identified. This work highlights the ability of the global CF community to unify and address critical issues facing pwCF.

引用

页码：815 / 822

页数：8

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