PhI(OAc)2-Promoted Site-Selective C-H Chlorination of (Hetero)arenes with p-Toluenesulfonyl Chloride

被引：0

作者：

Tang, Junyang ^{[1
]}

Liu, Yaorong ^{[1
]}

Qiu, Baojie ^{[1
]}

Zhang, Zhuo ^{[1
]}

Zhang, Xingxian ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China

来源：

ORGANIC LETTERS | 2024年 / 26卷 / 41期

基金：

中国国家自然科学基金;

关键词：

MECHANISMS;

D O I：

10.1021/acs.orglett.4c03017

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and practical system for metal-free catalytic chlorination of (hetero)arenes by using readily available and inexpensive TsCl and PhI(OAc)(2) is described. This newly developed protocol has been achieved by the nonsymmetric iodane generated by a combination of PhI(OAc)(2) and TsCl. The broad substrate scope, good functional group tolerance, excellent regioselectivity, and short reaction times make this method attractive for the late-stage chlorination of complex drug-like scaffolds.

引用

页码：8708 / 8712

页数：5

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