PhI(OAc)2-Promoted Site-Selective C-H Chlorination of (Hetero)arenes with p-Toluenesulfonyl Chloride

被引：0
|
作者：
Tang, Junyang [1 ]
Liu, Yaorong [1 ]
Qiu, Baojie [1 ]
Zhang, Zhuo [1 ]
Zhang, Xingxian [1 ]
机构：
[1] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Peoples R China
来源：
ORGANIC LETTERS | 2024年 / 26卷 / 41期
基金：
中国国家自然科学基金;
关键词：
MECHANISMS;
D O I：
10.1021/acs.orglett.4c03017
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and practical system for metal-free catalytic chlorination of (hetero)arenes by using readily available and inexpensive TsCl and PhI(OAc)(2) is described. This newly developed protocol has been achieved by the nonsymmetric iodane generated by a combination of PhI(OAc)(2) and TsCl. The broad substrate scope, good functional group tolerance, excellent regioselectivity, and short reaction times make this method attractive for the late-stage chlorination of complex drug-like scaffolds.
引用
收藏
页码：8708 / 8712
页数：5
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