SYNTHESIS OF SUBSTITUTED 2-AMINO OXAZOLES WITH THEIR COBALT(II) AND PLATINUM(IV) COMPLEXES AND EVALUATION OF THEIR BIOLOGICAL ACTIVITY

. In this research we successfully used substituted acetophenone or acetyl furan with urea in existence of iodine to synthesis novel substituted 2-amino oxazoles (1-3) from substituted acetophenone or acetyl furan with urea in presence of iodine. The structures of (1-3) were proved by spectroscopic methods (IR, H-1 NMR, C-13 NMR, and C.H.N.). Compounds (1-3) were used in 2:1 ratio to synthesis of three complexes by Reaction with (CoCl2.6H(2)O)(4-6), and three complexes by reaction with (PtCl4) (7-9) respectively in the presence of triethylamine in absolute ethanol. The thermal analysis (TGA), magnetic characteristics, and differential thermal analysis (DTA) was studied. Number of manufactured compounds were assessed versus the growth of four kinds of bacteria.