PLATINUM(II), PLATINUM(IV), AND PALLADIUM(II) COMPLEXES OF AMINO SUBSTITUTED PHOSPHINE OXIDES - SYNTHESIS, CHARACTERIZATION, AND ANTITUMOR-ACTIVITY

被引：40

作者：

DODOFF, N ^{[1
]}

VARBANOV, S ^{[1
]}

BORISOV, G ^{[1
]}

SPASSOVSKA, N ^{[1
]}

机构：

[1] BULGARIAN ACAD SCI,CENT LAB POLYMERS,BU-1113 SOFIA,BULGARIA

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 1990年 / 39卷 / 03期

关键词：

D O I：

10.1016/0162-0134(90)84003-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The complexes [Pt(dapo)2Cl2], [PtNH3(dapo)Cl2], [Pt(py)(dapo)Cl2], [Pt(mbpo)Cl2]·H2O, [Pt(mbpo)(OH)2Cl2]·H2O, [Pd(dapo)2Cl2], and [Pd(mbpo)Cl2], where dapo is dimethyl aminomethylphosphine oxide and mbpo is methyl bis(aminomethyl)phosphite oxide have been synthesized and characterized by elemental analyses, electric conductivity, infrared, 1H NMR and electronic spectra. The ligands are found to be coordinated only via the amino groups. The complexes are of cis-square planar configuration with the exception of [Pt(mbpo)(OH)2Cl2] ·H2O which is pseudo-octahedral. An in vivo antitumor screening of the complexes against Leukemia L 1210 was performed. A considerable activity (T/C = 233%) was observed for [PtNH3(dapo)Cl2]. The activity of the remaining complexes was below the accepted criterion. © 1990.

引用

页码：201 / 208

页数：8

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