Transition-Metal-Free Radical Approach for the Synthesis of Isothiocyanates by Pyridinium 1,4-Zwitterionic Thiolates as a Sulfur Source

被引：0

作者：

Abdiyan Mobarakeh, Fatemeh ^{[1
]}

Khosravi, Hormoz ^{[1
]}

Akbari, Alireza ^{[1
]}

Rominger, Frank ^{[2
]}

Balalaie, Saeed ^{[1
]}

机构：

[1] KN Toosi Univ Technol, Peptide Chem Res Inst, Tehran 1969764499, Iran

[2] Heidelberg Univ, Organ Chem Inst, D-69120 Heidelberg, Germany

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2025年 / 90卷 / 05期

基金：

美国国家科学基金会;

关键词：

CATALYZED SYNTHESIS; ISOCYANIDES; ISONITRILES; ANNULATION; DESULFURIZATION; CYCLOADDITION; CHEMISTRY; REAGENT; ACCESS;

D O I：

10.1021/acs.joc.4c02593

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we disclose a novel, mild, transition-metal-free approach to synthesizing diversely functionalized isothiocyanates from the corresponding isocyanide precursors, achieving high to excellent yields (up to 97%). The current method sheds light on the reactivity of pyridinium 1,4-zwitterionic thiolates as an unprecedented sulfur source strikingly distinct from their previously known reactivity in ionic annulation reactions, showcasing an innovative approach to organic synthesis.

引用

页码：1912 / 1921

页数：10

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