Using multistate models and polygenic risk scores to understand cardiometabolic disease in British Pakistani and Bangladeshi populations: showcasing the Genes and Health cohort

被引:0
|
作者
Stow, D. [1 ]
Tsang, R. S. M. [2 ]
Katzourou, I. K. [3 ]
Eto, F. [1 ]
Samuel, M. [1 ]
Holmans, P. A. [3 ]
van den Bree, M. B. M. [3 ]
Siddiqui, M. K. [1 ]
Barroso, I. [4 ]
Timpson, N. J. [2 ]
Martin, H. C. M. [5 ]
Mathur, R. [1 ]
Finer, S. [1 ]
机构
[1] Queen Mary Univ London, Wolfson Inst Populat Hlth, London, England
[2] Univ Bristol, Bristol Med Sch, Bristol, Avon, England
[3] Cardiff Univ, Div Psychol Med & Clin Neurosci, Cardiff, S Glam, Wales
[4] Univ Exeter, Sch Med, Exeter, Devon, England
[5] Wellcome Sanger Inst, Cambridge, England
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
370
引用
收藏
页码:S187 / S188
页数:2
相关论文
共 13 条
  • [1] Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals
    Qin Qin Huang
    Neneh Sallah
    Diana Dunca
    Bhavi Trivedi
    Karen A. Hunt
    Sam Hodgson
    Samuel A. Lambert
    Elena Arciero
    John Wright
    Chris Griffiths
    Richard C. Trembath
    Harry Hemingway
    Michael Inouye
    Sarah Finer
    David A. van Heel
    R. Thomas Lumbers
    Hilary C. Martin
    Karoline Kuchenbaecker
    Nature Communications, 13
  • [2] Transferability of genetic loci and polygenic scores for cardiometabolic traits in British Pakistani and Bangladeshi individuals
    Huang, Qin Qin
    Sallah, Neneh
    Dunca, Diana
    Trivedi, Bhavi
    Hunt, Karen A.
    Hodgson, Sam
    Lambert, Samuel A.
    Arciero, Elena
    Wright, John
    Griffiths, Chris
    Trembath, Richard C.
    Hemingway, Harry
    Inouye, Michael
    Finer, Sarah
    van Heel, David A.
    Lumbers, R. Thomas
    Martin, Hilary C.
    Kuchenbaecker, Karoline
    NATURE COMMUNICATIONS, 2022, 13 (01)
  • [3] Partitioned polygenic scores and extremes of polygenic risk provide mechanistic insights into type 2 diabetes and gestational diabetes in British Pakistani and Bangladeshi populations
    Hodgson, S.
    Williamson, A.
    Stow, D.
    Jacobs, B. M.
    Samuel, M.
    Gafton, J.
    Zollner, J.
    Spreckler, M.
    Langenberg, C.
    van Heel, D. A.
    Mathur, R.
    Siddiqui, M. K.
    Finer, S.
    DIABETOLOGIA, 2024, 67 : S96 - S97
  • [4] Identification of phenotypically distinct subgroups of British Pakistani and Bangladeshi individuals with type 2 diabetes using clinical information and a polygenic risk score: Results from the Genes & Health Study
    Hodgson, S.
    Mathur, R.
    Huang, Q. Q.
    Lumbers, R. T.
    Kuchenbaecker, K.
    van Heel, D. A.
    Sallah, N.
    Griffiths, C. J.
    Newman, W. G.
    Trembath, R. C.
    Martin, H.
    Fine, S.
    DIABETIC MEDICINE, 2022, 39
  • [5] Data-driven clustering using clinical information and polygenic risk scores predicts complications in people with type 2 diabetes of Bangladeshi and Pakistani origin: Results from the Genes & Health study
    Hodgson, S.
    Huang, Q. Q.
    van Heel, D. A.
    Mathur, R.
    Martin, H. C.
    Finer, S.
    DIABETIC MEDICINE, 2021, 38
  • [6] Cohort Profile: East London Genes & Health (ELGH), a community-based population genomics and health study in British Bangladeshi and British Pakistani people
    Finer, Sarah
    Martin, Hilary C.
    Khan, Ahsan
    Hunt, Karen A.
    MacLaughlin, Beverley
    Ahmed, Zaheer
    Ashcroft, Richard
    Durham, Ceri
    MacArthur, Daniel G.
    McCarthy, Mark, I
    Robson, John
    Trivedi, Bhavi
    Griffiths, Chris
    Wright, John
    Trembath, Richard C.
    van Heel, David A.
    INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2020, 49 (01) : 20 - 21I
  • [7] Using Polygenic Risk Scores to Understand Baseline Disease Activity and Response to Treatment in Rheumatoid Arthritis
    Strathdee, J.
    Taylor, J.
    Bongartz, T.
    Robinson, J.
    Morgan, A.
    Barrett, J.
    HUMAN HEREDITY, 2015, 80 (03) : 121 - 121
  • [8] Investigating misclassification of type 1 diabetes in a population-based cohort of British Pakistanis and Bangladeshis using polygenic risk scores
    Liu, Timing
    Sankareswaran, Alagu
    Paterson, Gordon
    Fraser, Diane P.
    Hodgson, Sam
    Huang, Qin Qin
    Heng, Teng Hiang
    Ladwa, Meera
    Thomas, Nick
    van Heel, David A.
    Weedon, Michael N.
    Yajnik, Chittaranjan S.
    Oram, Richard A.
    Chandak, Giriraj R.
    Martin, Hilary C.
    Finer, Sarah
    SCIENTIFIC REPORTS, 2025, 15 (01):
  • [9] Validation of Polygenic Risk Scores for Coronary Heart Disease in a Middle Eastern Cohort Using Whole Genome Sequencing
    Saad, Mohamad
    El-Menyar, Ayman
    Kunji, Khalid
    Ullah, Ehsan
    Al Suwaidi, Jassim
    Kullo, Iftikhar J. J.
    CIRCULATION-GENOMIC AND PRECISION MEDICINE, 2022, 15 (06): : 504 - 515
  • [10] A type 2 diabetes polygenic risk score enhances prediction of incident diabetes compared to QDiabetes alone in British Pakistani and Bangladeshis: Results from the Genes and Health study
    Hodgson, S.
    Huang, Q. Q.
    Sallah, N.
    Lumbers, R. T.
    Kuchenbaecker, K.
    van Heel, D. A.
    Mathur, R.
    Griffiths, C. J.
    Newman, W. G.
    Trembath, R. C.
    Martin, H.
    Finer, S.
    DIABETIC MEDICINE, 2022, 39