Targeted Therapy for Prostate Cancer by Prostate-Specific Membrane Antigen-Targeted Small-Molecule Drug Conjugates

被引：0
|
作者：
Nakajima, Ryo [1 ]
机构：
[1] Hiroshima Univ, Dept Synthet Organ Chem, Grad Sch Biomed & Hlth Sci, 1-2-3 Kasumi,Minami ku, Hiroshima 7348553, Japan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2024年 / 72卷 / 02期
关键词：
prostate-specific membrane antigen; small-molecule drug conjugate; prostate cancer; targeted therapy; cleavable linker; PSMA INHIBITOR; RADIATION; LINKERS; DESIGN;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In the aging global population, prostate cancer is a worldwide health problem because the incidence rate of this disease increases at advanced ages. Although early-stage prostate cancer can be treated by total prostatectomy, the surgery causes side effects, such as incontinence and dysuria, that lower QOL. Once the disease progresses to metastatic castration-resistant prostate cancer (mCRPC), there are no effective chemotherapeutic agents without systematic side effects. Therefore, targeted therapies for mCPRC are urgently needed. Traditional antibody-drug conjugate treatments for prostate cancer have been tested in clinical trials and several side effects have been observed. Meanwhile, small-molecule drug conjugates (SMDCs) have certain advantages over antibody drug conjugates in terms of non-immunogenicity, reproducibility, and permeability. In this review, prostate- specific membrane antigen-targeted SMDCs for treating prostate cancer are summarized.
引用
收藏
页码：136 / 142
页数：7
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