Survival outcome of neoadjuvant endocrine therapy plus trastuzumab and pertuzumab (ET plus T plus P) vs. de-escalated chemotherapy (CT) plus T plus P in hormone receptor positive (HR+)/HER2+early breast cancer (EBC): WSG-TP-II trial

被引:0
|
作者
Gluz, O. [1 ]
Nitz, U. A. [2 ]
Christgen, M. [3 ]
Kummel, S. [4 ]
Holtschmidt, J. [5 ]
Schumacher, J. [6 ]
Hartkopf, A. D. [7 ]
Luedtke-Heckenkamp, K. [8 ]
Just, M. [9 ]
von Schumann, R. [10 ]
Polata, S. [11 ]
Schinkoethe, T. [12 ]
Graeser-Mayer, M. K. [13 ]
Kates, R. E. [14 ]
Wuerstlein, R. [15 ]
Kreipe, H. [3 ]
Harbeck, N. [16 ]
机构
[1] Evangeliches Krankenhaus Bethesda Klin, Breast Ctr, Monchengladbach, Germany
[2] West German Study Grp, Senol, Monchengladbach, Germany
[3] MHH, Pathol, Hannover, Germany
[4] Kliniken Essen Mitte Evang Huyssens Stiftung, Breast Unit, Essen, Germany
[5] St Elisabeth Clin Hohenlind, Breast Ctr, Cologne, Germany
[6] Palleos GmbH, Stat, Wiesbaden, Germany
[7] Univ Hosp Tubingen, Ctr Womens Hlth, Tubingen, Germany
[8] Niels Stensen Kliniken GmbH, Franziskus Hosp Harderberg, Oncol Dept, Georgsmarienhutte, Germany
[9] Onkol Schwerpunkt Praxis, Oncol, Greifswald, Germany
[10] Johanniter Bethesda Moenchengladbach, Breast Ctr Niederrhein, Monchengladbach, Germany
[11] Oncol Ctr Spandau, Oncol, Berlin, Germany
[12] LMU Klinikum Univ Munchen, Breast Ctr, Munich, Germany
[13] Westdeutsch Studiengrp GmbH, Senol, Monchengladbach, Germany
[14] Westdeutsch Studiengrp GmbH, Breast Ctr Dept, Monchengladbach, Germany
[15] LMU Klinikum Univ Munchen, Breast Ctr Dept, Munich, Germany
[16] LMU Univ Hosp, Dept Obstet & Gynecol, Breast Ctr, Munich, Germany
关键词
D O I
10.1016/j.annonc.2024.08.2255
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
LBA17
引用
收藏
页码:1210 / 1210
页数:1
相关论文
共 50 条
  • [21] Interim Results of BACH: Randomized Phase II Trial Evaluating the Safety of Two Chemotherapy Regimens as Adjuvant Therapy in Patients with HER2-Positive Breast Cancer: PLD plus Cyclophosphamide plus Trastuzumab (PLD plus C plus H), or Doxorubicin plus Cyclophosphomide (A plus C), Each Followed by Paclitaxel plus Trastuzumab (T plus H)
    Rayson, D.
    Suter, T.
    van der Vegt, S.
    Jackisch, C.
    Lluch, A.
    van den Bosch, J.
    Vivanco, Lopez G.
    Van Gent, Mathilde A.
    Wildiers, H.
    Provencher, L.
    Stopatschinskaja, S.
    Srinivasan, S.
    Richel, D.
    CANCER RESEARCH, 2009, 69 (24) : 620S - 620S
  • [22] Long-term outcomes of neoadjuvant trastuzumab emtansine plus pertuzumab (T-DM1+P) and docetaxel plus carboplatin plus trastuzumab plus pertuzumab (TCbHP) for HER2-positive primary breast cancer: results of the randomized phase 2 JBCRG20 study (Neo-peaks)
    Takano, Toshimi
    Masuda, Norikazu
    Ito, Mitsuya
    Inoue, Kenichi
    Tanabe, Yuko
    Kawaguchi, Kousuke
    Yasojima, Hiroyuki
    Bando, Hiroko
    Nakamura, Rikiya
    Yamanaka, Takashi
    Ishida, Kazushige
    Aruga, Tomoyuki
    Yanagita, Yasuhiro
    Tokunaga, Eriko
    Aogi, Kenjiro
    Ohno, Shinji
    Kasai, Hiroi
    Kataoka, Tatsuki R.
    Morita, Satoshi
    Toi, Masakazu
    BREAST CANCER RESEARCH AND TREATMENT, 2024, 207 (01) : 33 - 48
  • [23] Final analysis of WSG-ADAPT HER2+/HR+ phase-II-trial - efficacy, safety and predictive markers for 12-weeks of neoadjuvant T-DM1 with or without endocrine therapy versus Trastuzumab plus endocrine therapy in HER2-positive hormone-receptor-positive early breast cancer
    Braun, M.
    Gluz, O.
    Nitz, U.
    Christgen, M.
    Kuemmel, S.
    Schumacher, C.
    Potenberg, J.
    Kraemer, S.
    Kleine-Tebbe, A.
    Augustin, D.
    Aktas, B.
    Forstbauer, H.
    Tio, J.
    Liedtke, C.
    Kates, R. E.
    Wuerstlein, R.
    Kreipe, H. -H.
    Harbecks, N.
    ONCOLOGY RESEARCH AND TREATMENT, 2016, 39 : 2 - 2
  • [24] Interim overall survival analysis of APHINITY (BIG 4-11): A randomized multicenter, double-blind, placebo-controlled trial comparing chemotherapy plus trastuzumab plus pertuzumab versus chemotherapy plus trastuzumab plus placebo as adjuvant therapy in patients with operable HER2-positive early breast cancer
    Piccart, Martine
    Procter, Marion
    Fumagalli, Debora
    de Azambuja, Evandro
    Clark, Emma
    Ewer, Michael S.
    Restuccia, Eleonora
    Jerusalem, Guy
    Dent, Susan
    Reaby, Linda
    Bonnefoi, Herve
    Krop, Ian
    Liu, Tsang-Wu
    Pienkowski, Tadeusz
    Toi, Masakazu
    Wilcken, Nicolas
    Andersson, Michael
    Im, Young-Hyuck
    Tseng, Ling-Ming
    Lueck, Hans-Joachim
    Colleoni, Marco
    Monturus, Estefania
    Sicoe, Mihaela
    Guillaume, Sebastien
    Bines, Jose
    Gelber, Richard
    Viale, Giuseppe
    Thomssen, Christoph
    CANCER RESEARCH, 2020, 80 (04)
  • [25] Biomarker analysis from KAITLIN, a randomised phase III study of adjuvant trastuzumab emtansine (TDM-1; K) plus pertuzumab (P) versus trastuzumab (H) plus taxane (T) plus P after anthracyclines (AC) for high-risk HER2-positive early breast cancer (EBC)
    Metzger, O.
    Lambertini, C.
    Krop, I. E.
    Phillips, G. Lewis
    Perou, C. M.
    Symmans, F.
    Melero, I.
    Harbeck, N.
    Winer, E. P.
    Im, S-A.
    Barrios, C. H.
    Bonnefoi, H.
    Gralow, J. R.
    Ellis, P. A.
    Gianni, L.
    Toi, M.
    Swain, S. M.
    Boulet, T.
    Song, C.
    de Haas, S.
    ANNALS OF ONCOLOGY, 2021, 32 : S37 - S38
  • [26] Final analysis of WSG-ADAPT HER2+/HR+ phase II trial: Efficacy, safety, and predictive markers for 12-weeks of neoadjuvant TDM1 with or without endocrine therapy versus trastuzumab plus endocrine therapy in HER2-positive hormone-receptor positive early breast cancer
    Harbeck, N.
    Gluz, O.
    Christgen, M.
    Braun, M.
    Kuemmel, S.
    Schumacher, C.
    Potenberg, J.
    Kraemer, S.
    Kleine-Tebbe, A.
    Augustin, D.
    Aktas, B.
    Forstbauer, H.
    Tio, J.
    Liedtke, C.
    Kates, R. E.
    Wuerstlein, R.
    de Haas, S. L.
    Kiermaier, A.
    Kreipe, H. H.
    Nitz, U.
    CANCER RESEARCH, 2016, 76
  • [27] Results of multicenter phase II WSG Neo-Predict trial: Predictive markers for evaluation of response to neoadjuvant paclitaxel plus trastuzumab plus lapat in HER2-positive early breast cancer.
    Eichler, Christian
    Gluz, Oleg
    Nitz, Ulrike
    Christgen, Matthias
    Krabisch, Petra
    Hackenberg, Reinhard
    Skrobol, Markus
    Mobus, Volker
    Kates, Ronald
    Schumacher, Johannes
    Kreipe, Hans Heinrich
    Harbeck, Nadia
    Warm, Mathias
    JOURNAL OF CLINICAL ONCOLOGY, 2017, 35
  • [28] NATALEE: Phase III study of ribociclib (RIBO) plus endocrine therapy (ET) as adjuvant treatment in hormone receptor-positive (HR plus ), human epidermal growth factor receptor 2-negative (HER2-) early breast cancer (EBC).
    Slamon, Dennis J.
    Fasching, Peter A.
    Patel, Ravindranath
    Verma, Sunil
    Hurvitz, Sara A.
    Chia, Stephen K. L.
    Crown, John
    Martin, Miguel
    Barrios, Carlos H.
    Spera, Gonzalo
    Lopez, Celine
    Hor, Ines
    Pelov, Diana
    Hughes, Gareth
    Nawinne, Moditha
    Hortobagyi, Gabriel N.
    JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (15)
  • [29] Primary analysis of KAITLIN: A phase Ill study of trastuzumab emtansine (T-DM1) + pertuzumab versus trastuzumab plus pertuzumab plus taxane, after anthracyclines as adjuvant therapy for high-risk HER2-positive early breast cancer (EBC).
    Harbeck, Nadia
    Im, Seock-Ah
    Barrios, Carlos H.
    Bonnefoi, Herve R.
    Gralow, Julie
    Toi, Masakazu
    Ellis, Paul
    Gianni, Luca
    Swain, Sandra M.
    Im, Young-Hyuck
    De Laurentiis, Michelino
    Nowecki, Zbigniew
    Shah, Jigna
    Boulet, Thomas
    Liu, Haiying
    Macharia, Harrison
    Trask, Peter
    Song, Chunyan
    Winer, Eric P.
    Krop, Ian E.
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (15)
  • [30] Ribociclib (RIB) plus endocrine therapy (ET) in Japanese women with hormone receptor-positive (HR+), HER2-negative (HER2-) advanced breast cancer (ABC)
    Masuda, N.
    Noguchi, S.
    Ishikawa, T.
    Aruga, T.
    Kim, S. J.
    Toyama, T.
    Saeki, T.
    Saito, M.
    Yamanaka, T.
    Watanabe, J.
    Nakamura, S.
    Takahashi, M.
    Inoue, K.
    Gounaris, I.
    Han, Y.
    Samant, T. S.
    Gazdoiu, M.
    Ito, Y.
    ANNALS OF ONCOLOGY, 2018, 29