A new pyrrolopyrazine alkaloid from the fruit of Lycium chinense

被引：0

作者：

Liu, Hui ^{[1
]}

Fan, Yu-Xin ^{[1
]}

Xu, Rui-Wen ^{[1
]}

Zhu, Yan-Jie ^{[1
]}

Xue, Gui-Min ^{[1
,2
]}

Sun, Yan-Jun ^{[1
,2
]}

Feng, Wei-Sheng ^{[1
,2
]}

Chen, Hui ^{[1
,2
]}

机构：

[1] Henan Univ Chinese Med, Sch Pharm, Zhengzhou 405600, Peoples R China

[2] Henan Univ Chinese Med, Collaborat Innovat Ctr Resp Dis Diag Treatment & C, Zhengzhou 405600, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2025年

基金：

中国国家自然科学基金;

关键词：

Solanaceae; Lycium chinense; pyrrolopyrazine alkaloid; alpha-glucosidase inhibitory activity; PYRROLE ALKALOIDS;

D O I：

10.1080/10286020.2025.2475481

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new pyrrolopyrazine alkaloid, named lycipyrazine A (1), alone with seven known alkaloids (2-8), were isolated from the fruit of Lycium chinense. The structure of new compound 1 was determined using extensive 1D and 2D spectroscopic analyses, while its absolute configuration was determined by comparison of its experimental and calculated ECD spectra. Their alpha-glucosidase inhibitory activity was screened using acarbose as a positive control. Compound 4 showed strong inhibitory activity against alpha-glucosidase (IC50 = 3.04 +/- 0.38 mu M). This study enriched the structural diversity of alkaloids in L. chinense and provided further clues for searching new antidiabetic agents from natural sources.

引用

页数：6

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