Evolution of Gleason Score Prostate - A Review

Gleason grading system was first introduced in the 1960s by Dr. Donald Gleason and has since been used worldwide for the grading of prostate cancer. Over the years it has undergone several modifications but has still retained its status as the most popular scoring system for prostate. Using a systematic literature review, we aim to highlight the changes the Gleason scoring has undergone, their strengths and limitations as well the future directives. Gleason scoring underwent major changes from its original conception in the International Society of Urologic Pathology (ISUP) consensus meetings held in 2005, 2014 and 2019. The latest change in Gleason scoring makes it possible to report the scoring, help alleviate patient anxiety and has shown good reproducibility and less inter-user variability. Gleason scoring system is a popular tool among pathologists and clinicians alike owing to its flexibility, utility and dependability. With advancements in the medical field and the use of artificial intelligence, it is expected to undergo further tempering.