Visible-light-induced radical cascade cyclization of 2-isocyanobiaryls via 1,5-hydrogen atom transfer (1,5-HAT)

被引：0

作者：

Zhu, Yafei ^{[1
,2
]}

Zhang, Penghua ^{[3
]}

Tian, Xingqin ^{[3
,4
]}

Wang, Xueqin ^{[3
]}

Wang, Mi ^{[1
,2
]}

Zhang, Cuimei ^{[1
,2
]}

Chen, Jian ^{[1
,2
]}

Zhang, Jing ^{[3
]}

Lv, Guanghui ^{[1
,2
,3
]}

Wu, Yong ^{[1
,2
]}

机构：

[1] Sichuan Univ, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Educ Minist, 17 Southern Renmin Rd, Chengdu 610041, Sichuan, Peoples R China

[2] Sichuan Univ, West China Sch Pharm, Dept Med Chem, 17 Southern Renmin Rd, Chengdu 610041, Sichuan, Peoples R China

[3] Hubei Univ Med, Taihe Hosp, Hubei Prov Clin Res Ctr Umbil Cord Blood Hematopoi, Dept Pharm, Shiyan 442000, Hubei, Peoples R China

[4] Hubei Univ Med, Taihe Hosp, Hubei Prov Clin Res Ctr Umbil Cord Blood Hematopoi, Dept Combine Tradit Chinese & Western Med, Shiyan 442000, Hubei, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2025年

关键词：

ALKYLATION;

D O I：

10.1039/d5qo00031a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we reported the first attractive example of visible-light-induced radical cascade cyclization of 2-isocyanobiaryls for the synthesis of phenanthridines via 1,5-hydrogen atom transfer. The reaction circumvents the need for a base, metals, and high temperature, enabling the preparation of phenanthridines with a broad substrate scope and excellent functional group compatibility.

引用

页数：8

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