Effects of antipsychotic treatment on cardio-cerebrovascular related mortality in schizophrenia: A subanalysis of a systematic review and meta-analysis with meta-regression of moderators

被引：3

作者：

Solmi, Marco ^{[1
,2
,3
,4
,5
,6
]}

Croattog, Giovanni ^{[7
]}

Gupta, Arnav ^{[8
,9
]}

Fabianoa, Nicholas ^{[1
,6
]}

Wong, Stanley ^{[6
,10
]}

Fornaro, Michele ^{[11
]}

Schneiderl, Lynne Kolton ^{[12
]}

Rohani-Montez, S. Christy ^{[12
]}

Fairleyl, Leanne ^{[12
]}

Smithl, Nathalie ^{[12
]}

Bitterm, Istvan ^{[13
]}

Gorwoodn, Philip ^{[14
,15
]}

Taipalep, Heidi ^{[16
,17
,18
,19
]}

Tiihonenp, Jari ^{[16
,17
,18
]}

Cortese, Samuele ^{[20
,21
,22
,23
,24
]}

Dragioti, Elena ^{[25
,26
]}

Du Rietz, Ebba ^{[27
]}

Nielsen, Rene Ernst ^{[28
,29
]}

Firth, Joseph ^{[30
]}

Fusar-Poli, Paolo ^{[31
,32
,33
,34
]}

Hartman, Catharina ^{[35
]}

Holt, Richard I. G. ^{[36
]}

Hoye, Anne ^{[37
]}

Koyanagi, Ai ^{[38
,39
]}

Larsson, Henrik ^{[27
,40
]}

Lehto, Kelli ^{[41
]}

Lindgren, Peter ^{[42
,43
]}

Manchia, Mirko ^{[44
,45
,46
]}

Nordentoft, Merete ^{[47
]}

Skonieczna-Zydecka, Karolina ^{[48
]}

Stubbs, Brendon ^{[49
]}

Vancampfortay, Davy ^{[50
,51
]}

De Prisco, Michele ^{[52
]}

Boyer, Laurent ^{[53
]}

Vieta, Eduard ^{[52
]}

Correlle, Christoph U. ^{[54
,55
]}

机构：

[1] Univ Ottawa, Dept Psychiat, 501 Smyth Rd, Ottawa, ON, Canada

[2] Ottawa Hosp, Dept Mental Hlth, Ottawa, ON, Canada

[3] Univ Ottawa, Ottawa Hosp Res Inst, Clin Epidemiol Program, Ottawa, ON, Canada

[4] Univ Ottawa, Fac Med, Sch Epidemiol & Publ Hlth, Ottawa, ON, Canada

[5] Charite, Dept Child & Adolescent Psychiat, Berlin, Germany

[6] Univ Ottawa, Dept Psychiat, Sci Lab, Ottawa, ON, Canada

[7] AULSS 3 Serenissima, Mental Hlth Dept, Venice, Italy

[8] Univ Calgary, Dept Med, Calgary, AB, Canada

[9] Kent State Univ, Coll Publ Hlth, Kent, OH USA

[10] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[11] Federico II Univ Naples, Dept Neurosci Reprod Sci & Dent, Sect Psychiat, Naples, Italy

[12] WebMD Global LLC, London, England

[13] Semmelweis Univ, Dept Psychiat & Psychotherapy, Budapest, Hungary

[14] Univ Paris Cite, Inst Psychiat & Neurosci Paris IPNP, INSERM, U1266, Paris, France

[15] St Anne Hosp, GHU Paris Psychiat & Neurosci CMME, Paris, France

[16] Karolinska Inst, Dept Clin Neurosci, Stockholm, Sweden

[17] Stockholm City Council, Ctr Psychiat Res, Stockholm, Sweden

[18] Univ Eastern Finland, Niuvanniemi Hosp, Dept Forens Psychiat, Kuopio, Finland

[19] Univ Eastern Finland, Sch Pharm, Kuopio, Finland

[20] Univ Southampton, Fac Environm & Life Sci, Ctr Innovat Mental Hlth, Sch Psychol, Southampton, England

[21] Solent NHS Trust, Southampton, England

[22] Univ Southampton, Fac Med, Clin & Expt Sci CNS & Psychiat, Southampton, England

[23] NYU, NYU Langone, Hassenfeld Childrens Hosp, Child Study Ctr, New York, NY USA

[24] Univ Bari Aldo Moro, DiMePRe J Dept Precis & Regenerat Med Jonic Area, Bari, Italy

[25] Linkoping Univ, Pain & Rehabil Ctr, Dept Med & Hlth Sci, Linkoping, Sweden

[26] Univ Ioannina, Sch Hlth Sci, Dept Nursing, Res Lab Psychol Patients Families & Hlth Profess, Ioannina, Greece

[27] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[28] Aalborg Univ, Dept Clin Med, Aalborg, Denmark

[29] Aalborg Univ Hosp, Dept Psychiat, Aalborg, Denmark

[30] Univ Manchester, Manchester Acad Hlth Sci Ctr, Div Psychol & Mental Hlth, Manchester, England

[31] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, Early Psychosis Intervent & Clin Detect EPIC Lab, London, England

[32] South London & Maudlsey SLaM NHS Fdn Trust, Outreach & Support South London OASIS Serv, London, England

[33] Univ Pavia, Dept Brain & Behav Sci, Pavia, Italy

[34] Ludwig Maximilian Univ LMU Hosp, Dept Psychiat & Psychotherapy, Munich, Germany

[35] Univ Groningen, Univ Med Ctr Groningen, Interdisciplinary Ctr Psychopathol & Emot Regulat, Dept Psychiat, Groningen, Netherlands

[36] Univ Southampton, Fac Med, Human Dev & Hlth, Southampton, England

[37] Univ Hosp Southampton NHS Fdn Trust, Southampton Natl Inst, Hlth Res Biomed Res Ctr, Southampton, England

[38] ISCIII, Res & Dev Unit, Parc Sanit St Joan Deu, CIBERSAM, 42 St Boi de Llobregat, Barcelona 08830, Spain

[39] ICREA, Pg Lluis Co 23, Barcelona 08010, Spain

[40] Orebro Univ, Sch Med Sci, Orebro, Sweden

[41] Univ Tartu, Inst Genom, Estonian Genome Ctr, Tartu, Estonia

[42] Karolinska Inst, Dept Learning Informat Management & Eth, Stockholm, Sweden

[43] Swedish Inst Hlth Econ, Lund, Sweden

[44] Univ Cagliari, Dept Med Sci & Publ Hlth, Sect Psychiat, Cagliari, Italy

[45] Univ Hosp Agcy Cagliari, Unit Clin Psychiat, Cagliari, Italy

[46] Dalhousie Univ, Dept Pharmacol, Halifax, NS, Canada

[47] Copenhagen Univ Hosp, Mental Hlth Ctr Copenhagen, Dept Clin Med, Copenhagen, Denmark

[48] Pomeranian Med Univ, Dept Biochem Sci, Szczecin, Poland

[49] Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychol Med, London, England

[50] Katholieke Univ Leuven, Dept Rehabil Sci, Leuven, Belgium

来源：

EUROPEAN NEUROPSYCHOPHARMACOLOGY | 2024年 / 88卷

关键词：

Schizophrenia; Mortality; Cardiovascular; Cerebrovascular; Antipsychotic; Systematic review; SUBSTANCE USE DISORDERS; MYOCARDIAL-INFARCTION; REGIONAL DIFFERENCES; PSYCHIATRIC-PATIENTS; BIPOLAR DISORDER; STOCKHOLM COUNTY; ALL-CAUSE; DEATH; COHORT; NATIONWIDE;

D O I：

10.1016/j.euroneuro.2024.07.009

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To further explore the role of different antipsychotic treatments for cardio-cerebrovascular mortality, we performed several subgroup, sensitivity and meta-regression analyses based on a large previous meta-analysis with schizophrenia, comparing antipsychotic treatment versus no antipsychotic. Quality assessment through the Newcastle-Ottawa Scale (NOS) and publication bias was measured. We meta-analyzed 53 different studies (schizophrenia patients: n = 2,513,359; controls: n = 360,504,484) to highlight the differential effects of antipsychotic treatment regimens on cardio-cerebrovascular-related mortality in incident and prevalent samples of tality in incident samples of schizophrenia (oral FGA [RR=2.20, 95 %CI=1.29-3.77, k = 1] and any FGA associated with reduced cardio-cerebrovascular-related mortality, in prevalent samples of schizophrenia. Subdemonstrated a larger association between antipsychotics and decreased risk of mortality with longer follow-up, recent study year, and higher number of adjustment variables. Overall, this subanalysis of a systematic review contributes to the evolving understanding of the complex role of antipsychotic treatment for cardiocerebrovascular mortality in schizophrenia, paving the way for more targeted interventions and improved pa

引用

页码：6 / 20

页数：15

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