Preparation and properties of inclusion complex of resveratrol with epichlorohydrin-modified (3-cyclodextrin

被引：0
|
作者：
Li, Shide [1 ]
Luo, Hongsheng [1 ]
Qiu, Ronghua [1 ]
Huang, Kaibin [1 ]
Chen, Ziying [1 ]
Fu, Xiangjun [2 ]
机构：
[1] Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou 510006, Peoples R China
[2] Guangdong Second Prov Gen Hosp, Dept Otorhinolaryngol Head & Neck Surg, Guangzhou 510317, Peoples R China
来源：
MATERIALS LETTERS | 2025年 / 381卷
关键词：
Thermal stability; Working synergistically; Biomaterials; Composite materials; Powder technology;
D O I：
10.1016/j.matlet.2024.137780
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
In order to improve the aqueous solubility and enhance stability of resveratrol (RES), an inclusion complex (RESECH-(3CD) of RES with epichlorohydrin-modified (3-cyclodextrin (ECH-(3CD) was prepared using freeze-drying. The effects of RES-ECH-(3CD on the solubility and stability of RES were investigated. Phase solubility studies indicated that ECH-(3CD significantly enhanced the solubility of RES compared to (3-cyclodextrin ((3-CD). Thermal stability tests showed that the inclusion complex exhibited superior thermal stability compared to free RES. Furthermore, the application of RES-ECH-(3CD in sunscreen formulations was validated. The formulation exhibited sun protection properties, with RES-ECH-(3CD working synergistically with a-glucosyl rutin (Rutin-G) to significantly enhance both SPF and PFA. These findings suggest that RES-ECH-(3CD not only improves the solubility and stability of RES but also has promising potential for use in cosmetic and sunscreen products.
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页数：4
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