Iron-Catalyzed Reductive Deoxygenation of Nitroarenes to Access N-Heterocycles

被引：0

作者：

Lin, Ziyi ^{[1
,2
]}

Zhang, Ruichen ^{[1
]}

Huang, Hong ^{[1
]}

Guo, Bohao ^{[2
]}

Xian, Pengjie ^{[1
]}

Qiao, Chang ^{[2
]}

Feng, Zhang ^{[1
,2
]}

机构：

[1] North Sichuan Med Coll, Med Imaging Key Lab Sichuan Prov, Nanchong 637000, Peoples R China

[2] Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, Chongqing 401331, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2025年

基金：

中国国家自然科学基金;

关键词：

iron catalysis; reductive coupling; Deoxygenation; Nitroarene; <italic>N</italic>-heterocycles; O-NITROSTYRENES;

D O I：

10.1002/adsc.202401531

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Herein, we present the example of iron-catalyzed reductive amination of nitroarenes under the iron/borane system, providing diverse N-heterocycles in moderate to good yields. This transformation has high efficiency, broad substrate scope, and good functional group compatibility. Preliminary mechanistic studies indicate that hydroxylamines derived from nitrosoarenes may serve as crucial intermediates rather than anilines, and free organic radicals may not participate in the catalytic cycle.

引用

页数：7

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