AgOTf-catalyzed cascade annulation of 5-hexyn-1-ols and aldehydes: enabling the diastereoselective synthesis of [6,6,6]-trioxa-fused ketals and hexahydro-2H-chromenes

被引：0

作者：

Vinodkumar, Ramavath ^{[1
,2
]}

Nakate, Ashwini K. ^{[1
,2
]}

Krishna, Gamidi Rama ^{[2
,3
]}

Kontham, Ravindar ^{[1
,2
]}

机构：

[1] Natl Chem Lab, Organ Chem Div, CSIR, Dr Homi Bhabha Rd, Pune 411008, India

[2] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India

[3] Natl Chem Lab, Ctr Mat Characterizat, CSIR, Dr Homi Bhabha Rd, Pune 411008, India

来源：

CHEMICAL COMMUNICATIONS | 2025年 / 61卷 / 05期

关键词：

D O I：

10.1039/d4cc05546b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report the unprecedented diastereoselective synthesis of novel [6,6,6]-trioxa-fused ketals via AgOTf-catalyzed cascade annulation of 5-hexyn-1-ols (with primary or secondary hydroxyl groups) and aldehydes through a [2+2+1+1] pathway. In contrast, 5-hexyn-1-ols with tertiary hydroxyl groups yield hexahydro-2H-chromenes via a [3+1+1+1] pathway.

引用

页码：973 / 976

页数：4

共 17 条

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