Pd-catalyzed asymmetric etherification of 2H-chromenes: enantioselective construction of chiral 4-alkoxy-4H-chromenes

被引：0

作者：

Wang, Bangzhong ^{[1
]}

Sun, Luyang ^{[2
]}

Zhang, Pengyue ^{[1
]}

Zhang, Shuaibo ^{[1
]}

Zhao, Jinfeng ^{[3
]}

Qu, Jingping ^{[2
]}

Zhou, Yuhan ^{[1
]}

机构：

[1] Dalian Univ Technol, Sch Chem Engn, Dept Pharmaceut Engn, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China

[2] Dalian Univ Technol, Sch Chem Engn, State Key Lab Fine Chem, 2 Linggong Rd, Dalian 116024, Peoples R China

[3] Dalian Univ Technol, Instrumental Anal Ctr, 2 Linggong Rd, Dalian 116024, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2025年 / 23卷 / 14期

基金：

中国国家自然科学基金;

关键词：

ORGANOCATALYTIC CONJUGATE ADDITION; ORTHO-QUINONE METHIDES; MICHAEL ADDITION; MALONONITRILE; DERIVATIVES; CYCLIZATION; DISCOVERY; 2-AMINO-4H-CHROMENES; 4H-CHROMENES; ALKYLATION;

D O I：

10.1039/d5ob00005j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new strategy for the construction of a chiral 4-alkoxy-4H-chromene skeleton was reported. A series of chiral 4-alkoxy-4H-chromenes containing the trifluoromethyl group were obtained in good yields (up to 80% yield) and excellent enantioselectivity (up to 93% ee).

引用

页码：3431 / 3436

页数：6

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