Curcumin enhances bedaquiline's efficacy against Mycobacterium abscessus: in vitro and in vivo evidence

被引：0
|
作者：
Luo, Dan [1 ,2 ]
Xie, Weile [1 ,2 ]
Wang, Zhe [1 ,2 ]
机构：
[1] Shanghai Jiao Tong Univ, Sch Agr & Biol, Shanghai Key Lab Vet Biotechnol, Shanghai, Peoples R China
[2] Shanghai Jiao Tong Univ, Collaborat Innovat Ctr Agriseeds, Sch Agr & Biol, Shanghai, Peoples R China
来源：
MICROBIOLOGY SPECTRUM | 2025年
关键词：
Mycobacterium abscessus; bedaquiline; curcumin; synergy; combination; ATP SYNTHASE; RESISTANCE; DISEASE; ROLES;
D O I：
10.1128/spectrum.02295-24
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
In this study, we describe the combined effects of bedaquiline (BDQ) and the natural product curcumin (CUR) on Mycobacterium abscessus. In both in vitro and in vivo experiments, CUR enhanced BDQ's inhibitory effect. This combination reduced M. abscessus survival under nutrient-deprived, hypoxic, and acidic conditions, accelerated ATP depletion, mitigated BDQ-induced respiratory compensation, and effectively improved infection outcomes in both normal and immunosuppressed mice. Metabolomics analysis revealed that adding CUR to BDQ exacerbated BDQ-dependent downregulation of purine and pyrimidine metabolism and amino acid synthesis. Thus, BDQ-CUR combination therapy could potentially be applied to treat M. abscessus infections.
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页数：17
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