BACKGROUND: Neonatal sepsis is a major cause of morbidity and mortality among neonates. Nod-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a core element for innate immune protection. The study aims to estimate the expression of NLRP3 inflammasome in full term newborn infants who suffer from late onset sepsis, in order to assess its diagnostic value. METHOD: This case-control study was conducted in NICU. 40 newborns with late onset sepsis, and 40 control neonates were included. The analysis of NLRP3 inflammasome was done by ELISA. RESULTS: There was a significant elevation of NLRP3 inflammasome in the serum of neonates with late onset sepsis group than the control group, P values were < 0.001, and the best cut off value of NLRP3 to detect late onset septic was > 3 ng/ml with sensitivity of 92.5% and specificity of 97.5%. Receiver operating characteristic curve showed that the best cut off point of NLRP3 to predict mortality in cases group was > 7.29 with sensitivity of 75.0%, specificity of 91.67%, PPV of 50.0%, NPV of 97.1% and total accuracy of 0.84%. n-SOFA scoring system increased significantly among LOS group and there was positive correlation with NLRP 3 inflammasome, P < 0.012. CONCLUSION: NLRP3 inflammasome can be used for the diagnosis of late onset neonatal sepsis. The increase of its values was not affected by gender, birth weight, gestational age and postnatal age. It was the novel sepsis markers that were not fully studied in neonatal population. The prognostic values may need further studies.
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Tianjin Med Univ, Gen Hosp, Tianjin Neurol Inst, Dept Neurol, Tianjin, Peoples R ChinaTianjin Med Univ, Gen Hosp, Tianjin Neurol Inst, Dept Neurol, Tianjin, Peoples R China
Ren, Honglei
Kong, Ying
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Tianjin Med Univ, Gen Hosp, Tianjin Neurol Inst, Dept Neurol, Tianjin, Peoples R ChinaTianjin Med Univ, Gen Hosp, Tianjin Neurol Inst, Dept Neurol, Tianjin, Peoples R China
Kong, Ying
Liu, Zhijia
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Tianjin Med Univ, Gen Hosp, Tianjin Neurol Inst, Dept Neurol, Tianjin, Peoples R ChinaTianjin Med Univ, Gen Hosp, Tianjin Neurol Inst, Dept Neurol, Tianjin, Peoples R China
Liu, Zhijia
Zang, Dongyun
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Tianjin Huanhu Hosp, Dept Neurosurg, Tianjin, Peoples R ChinaTianjin Med Univ, Gen Hosp, Tianjin Neurol Inst, Dept Neurol, Tianjin, Peoples R China
Zang, Dongyun
Yang, Xiaoxia
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Tianjin Med Univ, Gen Hosp, Tianjin Neurol Inst, Dept Neurol, Tianjin, Peoples R ChinaTianjin Med Univ, Gen Hosp, Tianjin Neurol Inst, Dept Neurol, Tianjin, Peoples R China
Yang, Xiaoxia
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Wood, Kristofer
Li, Minshu
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Tianjin Med Univ, Gen Hosp, Tianjin Neurol Inst, Dept Neurol, Tianjin, Peoples R China
St Josephs Hosp, Barrow Neurol Inst, Dept Neurol, Phoenix, AZ USATianjin Med Univ, Gen Hosp, Tianjin Neurol Inst, Dept Neurol, Tianjin, Peoples R China
Li, Minshu
Liu, Qiang
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Tianjin Med Univ, Gen Hosp, Tianjin Neurol Inst, Dept Neurol, Tianjin, Peoples R China
St Josephs Hosp, Barrow Neurol Inst, Dept Neurol, Phoenix, AZ USATianjin Med Univ, Gen Hosp, Tianjin Neurol Inst, Dept Neurol, Tianjin, Peoples R China
机构:Capital Med Univ, Sch Publ Hlth, 10 Youanmen Outer West 1st St, Beijing 100069, Peoples R China
Jing, Li
Zheng, Dan
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机构:Capital Med Univ, Sch Publ Hlth, 10 Youanmen Outer West 1st St, Beijing 100069, Peoples R China
Zheng, Dan
Sun, Xuejing
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机构:Capital Med Univ, Sch Publ Hlth, 10 Youanmen Outer West 1st St, Beijing 100069, Peoples R China
Sun, Xuejing
Shi, Zhixiong
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Capital Med Univ, Sch Publ Hlth, 10 Youanmen Outer West 1st St, Beijing 100069, Peoples R China
Capital Med Univ, Beijing Key Lab Environm Toxicol, 10 Youanmen Outer West 1st St, Beijing 100069, Peoples R ChinaCapital Med Univ, Sch Publ Hlth, 10 Youanmen Outer West 1st St, Beijing 100069, Peoples R China
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Arak Univ Med Sci, Students Res Comm, Arak, IranArak Univ Med Sci, Students Res Comm, Arak, Iran
Asl, Hamideh Fallah
Mashayekhi, Farideh Jalali
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Arak Univ Med Sci, Sch Med, Dept Genet & Biochem, Arak, IranArak Univ Med Sci, Students Res Comm, Arak, Iran
Mashayekhi, Farideh Jalali
Zendedel, Adib
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Uniklin RWTH Aachen, Inst Neuroanat, D-52074 Aachen, GermanyArak Univ Med Sci, Students Res Comm, Arak, Iran
Zendedel, Adib
Baazm, Maryam
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Arak Univ Med Sci, Sch Med, Dept Anat, Basij Sq, Arak, Iran
Arak Univ Med Sci, Mol & Med Res Ctr, Arak, IranArak Univ Med Sci, Students Res Comm, Arak, Iran
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Department of Pharmacy, Chengdu University of Traditional Chinese Medicine
Department of Hepatology, The Fifth Medical Center of PLA General HospitalDepartment of Pharmacy, Chengdu University of Traditional Chinese Medicine
XiaoMei Zhao
ZhiXin Wu
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Department of Hepatology, The Fifth Medical Center of PLA General HospitalDepartment of Pharmacy, Chengdu University of Traditional Chinese Medicine
ZhiXin Wu
Yan Wang
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Department of Hepatology, The Fifth Medical Center of PLA General HospitalDepartment of Pharmacy, Chengdu University of Traditional Chinese Medicine
Yan Wang
YingJie Xu
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Department of Hepatology, The Fifth Medical Center of PLA General HospitalDepartment of Pharmacy, Chengdu University of Traditional Chinese Medicine
YingJie Xu
Ye Xiu
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机构:
Department of Hepatology, The Fifth Medical Center of PLA General HospitalDepartment of Pharmacy, Chengdu University of Traditional Chinese Medicine
Ye Xiu
Xu Dong
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Department of Hepatology, The Fifth Medical Center of PLA General HospitalDepartment of Pharmacy, Chengdu University of Traditional Chinese Medicine
Xu Dong
JunJie Li
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Department of Hepatology, The Fifth Medical Center of PLA General HospitalDepartment of Pharmacy, Chengdu University of Traditional Chinese Medicine
JunJie Li
GuiJi Lv
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Department of Hepatology, The Fifth Medical Center of PLA General HospitalDepartment of Pharmacy, Chengdu University of Traditional Chinese Medicine
GuiJi Lv
SiHao Wang
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Department of Hepatology, The Fifth Medical Center of PLA General HospitalDepartment of Pharmacy, Chengdu University of Traditional Chinese Medicine
SiHao Wang
YuRong Li
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Department of Military Patient Management, The Fifth Medical Center of PLA General HospitalDepartment of Pharmacy, Chengdu University of Traditional Chinese Medicine
YuRong Li
ZhaoFang Bai
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机构:
Department of Hepatology, The Fifth Medical Center of PLA General Hospital
Department of Hepatology, China Military Institute of Chinese Materia, The Fifth Medical Center of PLA General Hospital
Department of Hepatology, National Key Laboratory of KidneyDepartment of Pharmacy, Chengdu University of Traditional Chinese Medicine
ZhaoFang Bai
XiaoHe Xiao
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Department of Pharmacy, Chengdu University of Traditional Chinese Medicine
Department of Hepatology, The Fifth Medical Center of PLA General Hospital
Department of Hepatology, China Military Institute of Chinese Materia, The Fifth Medical Center of PLA General Hospital
Department of Hepatology, National Key Laboratory of KidneyDepartment of Pharmacy, Chengdu University of Traditional Chinese Medicine