The role of nod-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome in diagnosis of late onset neonatal sepsis

被引:1
|
作者
Mohamed, H. I. [1 ]
ELMeneza, S. A. [1 ]
El-Bagoury, I. M. S. [2 ]
机构
[1] AL Azhar Univ, Fac Med Girls, Pediat Dept, Elmokaiam Eldaym St, Cairo 1141, Egypt
[2] AL Azhar Univ, Fac Med Girls, Clin Pathol Dept, Cairo, Egypt
关键词
Late onset neonatal sepsis; neonatal SOFA score; newborn infants; NLRP3; inflammasome; non-survival newborn; EXPRESSION;
D O I
10.3233/NPM-210909
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
BACKGROUND: Neonatal sepsis is a major cause of morbidity and mortality among neonates. Nod-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is a core element for innate immune protection. The study aims to estimate the expression of NLRP3 inflammasome in full term newborn infants who suffer from late onset sepsis, in order to assess its diagnostic value. METHOD: This case-control study was conducted in NICU. 40 newborns with late onset sepsis, and 40 control neonates were included. The analysis of NLRP3 inflammasome was done by ELISA. RESULTS: There was a significant elevation of NLRP3 inflammasome in the serum of neonates with late onset sepsis group than the control group, P values were < 0.001, and the best cut off value of NLRP3 to detect late onset septic was > 3 ng/ml with sensitivity of 92.5% and specificity of 97.5%. Receiver operating characteristic curve showed that the best cut off point of NLRP3 to predict mortality in cases group was > 7.29 with sensitivity of 75.0%, specificity of 91.67%, PPV of 50.0%, NPV of 97.1% and total accuracy of 0.84%. n-SOFA scoring system increased significantly among LOS group and there was positive correlation with NLRP 3 inflammasome, P < 0.012. CONCLUSION: NLRP3 inflammasome can be used for the diagnosis of late onset neonatal sepsis. The increase of its values was not affected by gender, birth weight, gestational age and postnatal age. It was the novel sepsis markers that were not fully studied in neonatal population. The prognostic values may need further studies.
引用
收藏
页码:787 / 793
页数:7
相关论文
共 50 条
  • [1] Role and mechanism of the nod-like receptor family pyrin domain-containing 3 inflammasome in oral disease
    Lv, Kejia
    Wang, Guohua
    Shen, Chenlu
    Zhang, Xia
    Yao, Hua
    ARCHIVES OF ORAL BIOLOGY, 2019, 97 : 1 - 11
  • [2] NLRP3 (Nod-like receptor family, pyrin domain containing 3) inflammasome is increased in patients with primary progressive multiple sclerosis
    Malhotra, S.
    Sastre-Garriga, J.
    Castillo, J.
    Montalban, X.
    Comabella, M.
    MULTIPLE SCLEROSIS JOURNAL, 2015, 21 : 452 - 452
  • [3] Pharmacology of a Potent and Novel Inhibitor of the NOD-Like Receptor Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome that Attenuates Development of Nonalcoholic Steatohepatitis and Liver Fibrosis
    Povero, Davide
    Lazic, Milos
    McBride, Christopher
    Ambrus-Aikelin, Geza
    Stansfield, Ryan
    Johnson, Casey D.
    Santini, Angelina M.
    Pranadinata, Rama F.
    McGeough, Matthew D.
    Stafford, Jeffrey A.
    Hoffman, Hal M.
    Feldstein, Ariel E.
    Veal, James M.
    Bain, Gretchen
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2023, 386 (02): : 242 - 258
  • [4] Emerging role of exosomes in ulcerative colitis: Targeting NOD-like receptor family pyrin domain containing 3 inflammasome
    Li, Xin
    Ji, Li-Jiang
    Feng, Kai-Di
    Huang, Hua
    Liang, Mei-Rou
    Cheng, Shi-Jin
    Meng, Xiu-Dong
    WORLD JOURNAL OF GASTROENTEROLOGY, 2024, 30 (06) : 527 - 541
  • [5] Hepatic NOD-like receptors, pyrin domain-containing 3 (NLRP3) inflammasome activation is associated with histological severity in patients with nonalcoholic fatty liver disease
    Mitsuyoshi, Hironori
    Yasui, Kohichiroh
    Hara, Tasuku
    Taketani, Hiroyoshi
    Ishiba, Hiroshi
    Okajima, Akira
    Seko, Yuya
    Umemura, Atsushi
    Nishikawa, Taichiro
    Yamaguchi, Kanji
    Moriguchi, Michihisa
    Sumida, Yoshio
    Minami, Masahito
    Itoh, Yoshito
    HEPATOLOGY, 2015, 62 : 647A - 647A
  • [6] Pharmacological Inhibition of the Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome with MCC950
    Corcoran, Sarah E.
    Halai, Reena
    Cooper, Matthew A.
    PHARMACOLOGICAL REVIEWS, 2021, 73 (03) : 968 - 1000
  • [7] Discovery and optimization of 4-oxo-2-thioxo-thiazolidinones as NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inhibitors
    Chen, Yun
    He, Hongbin
    Jiang, Hua
    Li, Li
    Hu, Zhiyu
    Huang, Huiying
    Xu, Qingyan
    Zhou, Rongbin
    Deng, Xianming
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 30 (07)
  • [8] Targeting the NOD-, LRR- and Pyrin Domain-Containing Protein 3 (NLRP3) Inflammasome in Psoriasis and Fatigue
    Seguro, Charmaine Kue
    Beckler, Michelle Demory
    Kesselman, Marc M.
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2022, 14 (05)
  • [9] Small molecule inhibitor binds to NOD-like receptor family pyrin domain containing 3 and prevents inflammasome activation
    Lackner, Angela
    Cabral, Julia Elise
    Qiu, Yanfei
    Zhou, Haitian
    Leonidas, Lemuel
    Pham, Minh Anh
    Macapagal, Alijah
    Lin, Sophia
    Armanus, Emy
    McNulty, Reginald
    ISCIENCE, 2024, 27 (08)
  • [10] Targeting the NOD-Like Receptor Pyrin Domain Containing 3 Inflammasome to Improve Healing of Diabetic Wounds
    Cavalcante-Silva, Jacqueline
    Koh, Timothy J.
    ADVANCES IN WOUND CARE, 2023, 12 (11) : 644 - 656