Targeting protein modification: a new direction for immunotherapy of pancreatic cancer

被引：0

作者：

Ge, Xinyu ^{[1
]}

Zhang, Ke ^{[2
]}

Zhu, Jie ^{[1
]}

Chen, Yuan ^{[1
]}

Wang, Zhengwang ^{[1
]}

Wang, Peng ^{[1
]}

Xu, Peng ^{[1
]}

Yao, Jie ^{[1
]}

机构：

[1] Yangzhou Univ, Northern Jiangsu Peoples Hosp, Dept Hepatobiliary & Pancreat Surg, Yangzhou 225000, Jiangsu, Peoples R China

[2] Dalian Med Univ, Yangzhou Sch Clin Med, Yangzhou 225000, Jiangsu, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2025年 / 21卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Post-translational modifications; Immunotherapy; Targeted therapy; Immune escape; Pancreatic cancer; PD-L1; EXPRESSION; AUGMENTS IMMUNOTHERAPY; ACTIVATION; INHIBITION; PHOSPHORYLATION; GLYCOSYLATION; PATHWAY; GROWTH; CELLS; SUMO;

D O I：

10.7150/ijbs.101861

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Post-translational modifications (PTMs) alter protein conformation by covalently attaching functional groups to substrates, influencing their biological activity, mechanisms of action, and functional performance. PTMs and their interactions are essential to many critical signal transduction processes, including tumor transformation, cancer progression, and metastasis in pancreatic cancer. Additionally, advancements in tumor immunotherapy indicate that PTMs are essential in immune cell activation, transport, and energy metabolism. This study aimed to investigate the effects of different PTMs on immunotherapy for pancreatic cancer, providing new perspectives and suggesting directions for future research.

引用

页码：63 / 74

页数：12

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