Systematic Off-Target Analyses of Base-Editing Therapeutic Leads Show Reduced Off-Target Editing, Reduced Bystander Editing, and Increased On-Target Editing by Hybrid Guide RNAs

被引：0

作者：

Brooks, Dominique L. ^{[1
]}

Whittaker, Madelynn ^{[1
]}

Quigley, Aidan ^{[1
]}

Jindal, Ishaan ^{[1
]}

Ahrens-Nicklas, Rebecca ^{[2
]}

Musunuru, Kiran ^{[1
]}

Peranteau, William ^{[2
]}

Wang, Xiao ^{[1
]}

机构：

[1] Univ Penn, Cardiovasc Inst, Perelman Sch Med, Philadelphia, PA USA

[2] Childrens Hosp Philadelphia, Philadelphia, PA USA

来源：

MOLECULAR THERAPY | 2024年 / 32卷 / 04期

关键词：

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

679

引用

页码：343 / 344

页数：2

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