Systematic Off-Target Analyses of Base-Editing Therapeutic Leads Show Reduced Off-Target Editing, Reduced Bystander Editing, and Increased On-Target Editing by Hybrid Guide RNAs

被引：0
|
作者：
Brooks, Dominique L. [1 ]
Whittaker, Madelynn [1 ]
Quigley, Aidan [1 ]
Jindal, Ishaan [1 ]
Ahrens-Nicklas, Rebecca [2 ]
Musunuru, Kiran [1 ]
Peranteau, William [2 ]
Wang, Xiao [1 ]
机构：
[1] Univ Penn, Cardiovasc Inst, Perelman Sch Med, Philadelphia, PA USA
[2] Childrens Hosp Philadelphia, Philadelphia, PA USA
来源：
MOLECULAR THERAPY | 2024年 / 32卷 / 04期
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D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
679
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收藏
页码：343 / 344
页数：2
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