Cyclic Peptides Targeting Granzyme B: Potential Applications as PET Imaging Agents

被引：0

作者：

Hu, Qi-Long ^{[1
]}

Liang, Steven H. ^{[1
]}

机构：

[1] Emory Univ, Dept Radiol & Imaging Sci, Atlanta, GA 30322 USA

来源：

ACS MEDICINAL CHEMISTRY LETTERS | 2025年 / 16卷 / 02期

关键词：

D O I：

10.1021/acsmedchemlett.4c00608

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This patent application pertains to macrocyclic peptides and their radiolabeled derivatives, generally represented by Formula I. These compounds exhibit selective binding to Granzyme B (GzmB) and hold the potential for imaging disease or disorders associated with elevated GzmB levels. Such conditions include cancer immunotherapy, autoimmunity, wound healing, and inflammation.

引用

页码：180 / 181

页数：2

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