Synthesis and in vitro antimicrobial screening of some 5-methyl-2-substituted phenyl-3-(phenylsulfonyl)thiazolidin-4-ones

The synthesis of some new thiazolidine-sulfonamide derivatives was achieved in two steps. In the first step, appropriate aryl aldehyde reacted with benzene sulfonamide to yield N-arylidene benzene sulfonamide derivatives (1a-h ). In the second step, compounds (1a-h ) reacted with thiolactic acid to give the 5-methyl-2-substituted phenyl-3-(phenylsulfonyl) thiazolidin-4-one derivatives (2a-h ). The compounds 2a-h were screened for their in vitro antimicrobial activity by agar disc diffusion method. The results showed that compounds 2b, 2c, and 2d exhibited anti-microbial activity against the tested both Gram-positive and Gram-negative bacterial strains and compounds 2c, 2d, and 2g exhibited significant antifungal activity against fungal strains. The antimicrobial activity of tested compounds was compared with the standard antimicrobial drug ampicillin and antifungal drug clotrimazole.