Management strategies for patients with chronic lymphocytic leukaemia harbouring complex karyotype

被引：0

作者：

Serafin, Andrea ^{[1
]}

Ruocco, Valeria ^{[1
]}

Cellini, Alessandro ^{[1
]}

Angotzi, Francesco ^{[1
]}

Bonaldi, Laura ^{[2
]}

Trentin, Livio ^{[1
]}

Visentin, Andrea ^{[1
]}

机构：

[1] Univ Padua, Dept Med DIMED, Hematol Unit, via Nicolo Giustiniani, 2, I-35128 Padua, Italy

[2] Veneto Inst Oncol, Immunol & Mol Oncol Unit, Padua, Italy

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2025年 / 206卷 / 03期

关键词：

BTK inhibitors; chronic lymphocytic leukaemia; complex karyotype (CK); high-CK cytogenetic complexity; novel therapies; venetoclax; CHROMOSOMAL TRANSLOCATIONS; TELOMERE DYSFUNCTION; CLONAL EVOLUTION; TP53; MUTATIONS; CLL; RISK; TRANSFORMATION; IMPACT;

D O I：

10.1111/bjh.19986

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Chronic lymphocytic leukaemia (CLL) is a heterogeneous disease characterised by the uncontrolled proliferation of mature lymphocytes. A subset of CLL patients harbouring complex karyotype (CK) presents with poor prognosis and limited treatment options. This review aims to discuss the current understanding of such patient subset, including its molecular landscape, diagnostic approaches, treatment modalities and emerging therapies. Furthermore, it outlines strategies for personalised management to improve clinical outcomes in this challenging patient population.

引用

页码：832 / 841

页数：10

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