Inhibition of Dot1L histone methyltransferase activity promotes osteogenic differentiation

被引：0
|
作者：
Tress, Alexander [1 ]
Dauphinee, Drew [1 ]
Grzybowski, Alayna [1 ]
Stetsiv, Marta [1 ]
Sanjay, Archana [2 ]
Guzzo, Rosa [1 ]
机构：
[1] UConn Hlth, Farmington, CT USA
[2] UCHC, Farmington, CT USA
来源：
JOURNAL OF BONE AND MINERAL RESEARCH | 2023年 / 38卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
LB SUN-626
引用
收藏
页码：409 / 410
页数：2
相关论文
共 50 条
  • [41] A Potential Role of Histone Methyltransferase, Dot1l, in Renal Regulation of Acid-Base Balance
    Nakhoul, Nazih
    El-Dahr, Samir
    Brown, Karen
    Islam, M. Toriqul
    Khan, Altaf
    Hering-Smith, Kathleen
    Hamm, L. Lee
    Abdulnour-Nakhoul, Solange
    FASEB JOURNAL, 2015, 29
  • [42] Nonclinical pharmacokinetics and metabolism of EPZ-5676, a novel DOT1L histone methyltransferase inhibitor
    Basavapathruni, Aravind
    Olhava, Edward J.
    Daigle, Scott R.
    Therkelsen, Carly A.
    Jin, Lei
    Boriack-Sjodin, P. Ann
    Allain, Christina J.
    Klaus, Christine R.
    Raimondi, Alejandra
    Scott, Margaret Porter
    Dovletoglou, Angelos
    Richon, Victoria M.
    Pollock, Roy M.
    Copeland, Robert A.
    Moyer, Mikel P.
    Chesworth, Richard
    Pearson, Paul G.
    Waters, Nigel J.
    BIOPHARMACEUTICS & DRUG DISPOSITION, 2014, 35 (04) : 237 - 252
  • [43] Inhibition of histone methyltransferase DOT1L silences ERα gene and blocks proliferation of antiestrogen-resistant breast cancer cells
    Nassa, Giovanni
    Salvati, Annamaria
    Tarallo, Roberta
    Gigantino, Valerio
    Alexandrova, Elena
    Memoli, Domenico
    Sellitto, Assunta
    Rizzo, Francesca
    Malanga, Donatella
    Mirante, Teresa
    Morelli, Eugenio
    Nees, Matthias
    Akerfelt, Malin
    Kangaspeska, Sara
    Nyman, Tuula A.
    Milanesi, Luciano
    Giurato, Giorgio
    Weisz, Alessandro
    SCIENCE ADVANCES, 2019, 5 (02)
  • [44] CBP mediated DOT1L acetylation confers DOT1L stability and promotes cancer metastasis
    Liu, Chaohua
    Yang, Qiaoyan
    Zhu, Qian
    Lu, Xiaopeng
    Li, Meiting
    Hou, Tianyun
    Li, Zhiming
    Tang, Ming
    Li, Yinglu
    Wang, Hui
    Yang, Yang
    Wang, Haiying
    Zhao, Ying
    Wen, He
    Liu, Xiangyu
    Mao, Zebin
    Zhu, Wei-Guo
    THERANOSTICS, 2020, 10 (04): : 1758 - 1776
  • [45] Early mammalian erythropoiesis requires the Dot1L methyltransferase
    Feng, Yi
    Yang, Yanping
    Ortega, Manoela M.
    Copeland, Jessica N.
    Zhang, Mingcai
    Jacob, Jennifer B.
    Fields, Timothy A.
    Vivian, Jay L.
    Fields, Patrick E.
    BLOOD, 2010, 116 (22) : 4483 - 4491
  • [46] The histone methyltransferase DOT1L prevents antigen-independent differentiation and safeguards epigenetic identity of CD8+ T cells
    Kwesi-Maliepaard, Eliza Mari
    Aslam, Muhammad Assad
    Alemdehy, Mir Farshid
    van den Brand, Teun
    McLean, Chelsea
    Vlaming, Hanneke
    van Welsem, Tibor
    Korthout, Tessy
    Lancini, Cesare
    Hendriks, Sjoerd
    Ahrends, Tomasz
    van Dinther, Dieke
    den Haan, Joke M. M.
    Borst, Jannie
    de Wit, Elzo
    van Leeuwen, Fred
    Jacobs, Heinz
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2020, 117 (34) : 20706 - 20716
  • [47] Histone methyltransferase Dot1L inhibits pancreatic cancer cell apoptosis by promoting NUPR1 expression
    Lin Shan
    Chen Hao
    Zheng Jun
    Cai Qinghe
    JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, 2022, 50 (03)
  • [48] Structure of the catalytic domain of human DOT1L, a Non-SET domain nucleosomal histone methyltransferase
    Min, JR
    Feng, Q
    Li, ZZ
    Zhang, Y
    Xu, RM
    CELL, 2003, 112 (05) : 711 - 723
  • [49] INHIBITION OF DOT1L ACTIVITY IN HUMAN SKIN FIBROBLASTS: A TRANSCRIPTOME ANALYSIS
    Berghen, Nathalie
    De langhe, Ellen
    Lories, Rik
    ANNALS OF THE RHEUMATIC DISEASES, 2019, 78 : 1557 - 1557
  • [50] The Histone Methyltransferase DOT1L Is a Functional Component of Estrogen Receptor Alpha Signaling in Ovarian Cancer Cells
    Salvati, Annamaria
    Gigantino, Valerio
    Nassa, Giovanni
    Giurato, Giorgio
    Alexandrova, Elena
    Rizzo, Francesca
    Tarallo, Roberta
    Weisz, Alessandro
    CANCERS, 2019, 11 (11)
12345