Single-cell and spatial transcriptomic analyses revealing tumor microenvironment remodeling after neoadjuvant chemoimmunotherapy in non-small cell lung cancer

被引:0
|
作者
Xiaolu Cui [1 ]
Siyuan Liu [2 ]
He Song [3 ]
Jingjing Xu [4 ]
Yanbin Sun [2 ]
机构
[1] First Hospital of China Medical University,Department of Urology
[2] First Hospital of China Medical University,Department of Thoracic Surgery
[3] First Hospital of China Medical University,Department of Gastrointestinal Surgery
[4] Shengjing Hospital of China Medical University,Department of Rheumatology and Immunology
关键词
Non-small cell lung cancer; Single-cell RNA sequencing; Spatial transcriptome; Neoadjuvant chemoimmunotherapy; Tertiary lymphoid structures;
D O I
10.1186/s12943-025-02287-w
中图分类号
学科分类号
摘要
引用
收藏
相关论文
共 50 条
  • [21] Neoadjuvant Chemoimmunotherapy Increases Tumor Immune Lymphocytes Infiltration in Resectable Non-small Cell Lung Cancer
    Tianxiang Chen
    Zhengqi Cao
    Yingjia Sun
    Jia Huang
    Shengping Shen
    Yueping Jin
    Long Jiang
    Fengcai Wen
    Xiaochen Zhao
    Ding Zhang
    Yanan Chen
    Mengli Huang
    Hao Chen
    Shun Lu
    Ziming Li
    Annals of Surgical Oncology, 2023, 30 : 7549 - 7560
  • [22] Single-cell transcriptomics reveals tumor-infiltrating B cell function after neoadjuvant pembrolizumab and chemotherapy in non-small cell lung cancer
    Hou, Lingjie
    Zhang, Siyuan
    Yu, Wenwen
    Yang, Xuena
    Shen, Meng
    Hao, Xishan
    Ren, Xiubao
    Sun, Qian
    JOURNAL OF LEUKOCYTE BIOLOGY, 2023, 116 (03) : 555 - 564
  • [23] Sleeve lobectomy after neoadjuvant chemoimmunotherapy/chemotherapy for local advanced non-small cell lung cancer
    Liang, Hengrui
    Yang, Chao
    Gonzalez-Rivas, Diego
    Zhong, Yunpeng
    He, Ping
    Deng, Hongsheng
    Liu, Jun
    Liang, Wenhua
    He, Jianxing
    Li, Shuben
    TRANSLATIONAL LUNG CANCER RESEARCH, 2021, 10 (01) : 143 - 155
  • [24] Sleeve resection after neoadjuvant chemoimmunotherapy in the treatment of locally advanced non-small cell lung cancer
    Dai, Jie
    Zhu, Xinsheng
    Li, Dianke
    Huang, Yan
    Liu, Xiaogang
    He, Wenxin
    Duan, Liang
    Zhao, Deping
    Zhu, Yuming
    Chen, Chang
    Provencio, Mariano
    Ramirez, Robert A.
    Antonoff, Mara B.
    Wu, Chunyan
    Jiang, Gening
    TRANSLATIONAL LUNG CANCER RESEARCH, 2022, 11 (02) : 188 - 200
  • [25] Single-cell and spatial genomic landscape of non-small cell lung cancer brain metastases
    Tagore, Somnath
    Caprio, Lindsay
    Amin, Amit Dipak
    Bestak, Kresimir
    Luthria, Karan
    D'Souza, Edridge
    Barrera, Irving
    Melms, Johannes C.
    Wu, Sharon
    Abuzaid, Sinan
    Wang, Yiping
    Jakubikova, Viktoria
    Koch, Peter
    Brodtman, D. Zack
    Bawa, Banpreet
    Deshmukh, Sachin K.
    Ebel, Leon
    Ibarra-Arellano, Miguel A.
    Jaiswal, Abhinav
    Gurjao, Carino
    Biermann, Jana
    Shaikh, Neha
    Ramaradj, Priyanka
    Georgis, Yohanna
    Lagos, Galina G.
    Ehrlich, Matthew I.
    Ho, Patricia
    Walsh, Zachary H.
    Rogava, Meri
    Politis, Michelle Garlin
    Biswas, Devanik
    Cottarelli, Azzurra
    Rizvi, Nikhil
    Shu, Catherine A.
    Herzberg, Benjamin
    Anandasabapathy, Niroshana
    Sledge, George
    Zorn, Emmanuel
    Canoll, Peter
    Bruce, Jeffrey N.
    Rizvi, Naiyer A.
    Taylor, Alison M.
    Saqi, Anjali
    Hibshoosh, Hanina
    Schwartz, Gary K.
    Henick, Brian S.
    Chen, Fei
    Schapiro, Denis
    Shah, Parin
    Izar, Benjamin
    NATURE MEDICINE, 2025, : 1351 - 1363
  • [26] Single-cell RNA transcriptomic analyses of tumor microenvironment of ovarian metastasis in gastric cancer
    Chen, Guoyu
    Zhang, Mingda
    Lin, Xiaolin
    Shi, Qiqi
    Xu, Chenxin
    Sun, Bowen
    Xiao, Xiuying
    Feng, Haizhong
    CELLULAR ONCOLOGY, 2024, 47 (05) : 1911 - 1925
  • [27] Meta-Analysis Methods for Neoadjuvant Chemoimmunotherapy for Non-Small Cell Lung Cancer
    Zhang, Leisheng
    Li, Jing
    Guo, Liang
    JAMA ONCOLOGY, 2024, 10 (11) : 1595 - 1596
  • [28] Neoadjuvant chemoimmunotherapy in resectable stage IIIA/IIIB non-small cell lung cancer
    Chen, Yulong
    Yan, Bo
    Xu, Feng
    Hui, Zhenzhen
    Zhao, Gang
    Liu, Jie
    Zhang, Huan
    Zeng, Ziqing
    Zhang, Ran
    Provencio, Mariano
    Ren, Xiubao
    You, Jian
    TRANSLATIONAL LUNG CANCER RESEARCH, 2021, 10 (05) : 2193 - +
  • [29] Single-cell and spatial transcriptomic profiling reveal the cascade of immune events during progression and metastasis of non-small cell lung cancer
    Tian, Yanhua
    Li, Jian-Rong
    Zhu, Bo
    Fradette, Jared
    Chen, Hong
    Li, Chenyang
    Cui, Sijia
    Kraushaar, Daniel
    Fujimoto, Junya
    Rodriguez, Leticia
    Soto, Luisa Maren Solis
    Reuben, Alexandre
    Wistuba, Ignacio
    Gibbons, Don
    Chao, Cheng
    Zhang, Jianjun
    CANCER RESEARCH, 2023, 83 (07)
  • [30] Changes of tumor microenvironment in non-small cell lung cancer after TKI treatments
    Chen, Shanshan
    Tang, Jingyi
    Liu, Fen
    Li, Wei
    Yan, Ting
    Shangguan, Dangang
    Yang, Nong
    Liao, Dehua
    FRONTIERS IN IMMUNOLOGY, 2023, 14