The evolutionary advantage of artemisinin production by Artemisia annua

被引：1

作者：

Yin, Qinggang ^{[1
,2
,3
]}

Xiang, Li ^{[1
]}

Han, Xiaoyan ^{[4
]}

Zhang, Yujun ^{[1
]}

Lyu, Ruiqing ^{[2
,3
]}

Yuan, Ling ^{[2
,3
]}

Chen, Shilin ^{[5
]}

机构：

[1] China Acad Chinese Med Sci, Inst Chinese Mat Med, Artemisinin Res Ctr, State Key Lab Qual Ensurance & Sustainable Use Dao, Beijing 100700, Peoples R China

[2] Univ Kentucky, Dept Plant & Soil Sci, Lexington, KY 40546 USA

[3] Univ Kentucky, Kentucky Tobacco Res & Dev Ctr, Lexington, KY 40546 USA

[4] Chinese Acad Sci, Inst Bot, China Natl Bot Garden, Beijing 100093, Peoples R China

[5] Chengdu Univ Tradit Chinese Med, Inst Herbgenom, Chengdu 611137, Peoples R China

来源：

TRENDS IN PLANT SCIENCE | 2025年 / 30卷 / 02期

基金：

中国国家自然科学基金;

关键词：

TRANSCRIPTION FACTOR; GLANDULAR TRICHOMES; BIOSYNTHESIS; L; ACID; LOCALIZATION; EXPRESSION; MECHANISM; DISCOVERY; QINGHAOSU;

D O I：

10.1016/j.tplants.2024.09.006

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Artemisinin, a potent antimalarial compound, is predominantly derived from Artemisia annua. The uniqueness of artemisinin production in A. annua lies in its complex biochemical pathways and genetic composition, distinguishing it from other plant species, even within the Asteraceae family. In this review, we investigate the potential of A. annua for artemisinin production, drawing evidence from natural populations and mutants. Leveraging high-quality whole-genome sequence analyses, we offer insights into the evolution of artemisinin biosynthesis. We also highlight current understanding of the protective functions of artemisinin in A. annua in response to both biotic and abiotic stresses. In addition, we explore the mechanisms used by A. annua to mitigate the phytotoxicity generated by artemisinin catabolism.

引用

页码：213 / 226

页数：14

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