This paper investigates the design methodologies of pure rolling helical gear pumps with various tooth profiles, based on the active design of meshing lines. The transverse active tooth profile of a pure rolling helical gear end face is composed of various function curves at key control points. The entire transverse tooth profile consists of the active tooth profile and the Hermite curve as the tooth root transition, seamlessly connecting at the designated control points. The tooth surface is created by sweeping the entire transverse tooth profile along the pure rolling contact curves. The fundamental design parameters, tooth profile equations, tooth surface equations, and a two-dimensional fluid model for pure rolling helical gears were established. The pressure pulsation characteristics of pure rolling helical gear pumps and CBB-40 involute spur gear pumps, each with different tooth profiles, were compared under specific working pressures. This comparison encompassed the maximum effective positive and negative pressures within the meshing region, pressure fluctuations at the midpoints of both inlet and outlet pressures, and pressure fluctuations at the rear sections of the inlet and outlet pressures. The results indicated that the proposed pure rolling helical gear pump with a parabolic tooth profile exhibited 42.81% lower effective positive pressure in the meshing region compared to the involute spur gear pump, while the maximum effective negative pressure was approximately 27 times smaller than that of the involute gear pump. Specifically, the pressure pulsations in the middle and rear regions of the inlet and outlet pressure zones were reduced by 33.1%, 6.33%, 57.27%, and 69.61%, respectively, compared to the involute spur gear pump.