The role of irisin in exercise-induced muscle and metabolic health: a narrative review

被引：0
|
作者：
Mohammed, Sumaya Nadhim [1 ]
Jasim, Mohannad Hamid [2 ]
Mahmood, Shahad Hisham [2 ]
Saleh, Eman Naji [3 ]
Hashemzadeh, Alireza [4 ]
机构：
[1] Univ Al Maarif, Coll Hlth & Med Technol, Med Lab Tech Dept, Anbar, Iraq
[2] Univ Fallujah, Coll Educ, Dept Biol, Fallujah, Iraq
[3] Univ Anbar, Coll Educ Pure Sci, Dept Biol, Ramadi, Iraq
[4] Mashhad Univ Med Sci, Fac Med, Dept Clin Biochem, Mashhad, Iran
来源：
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY | 2025年
关键词：
Irisin; Aerobic exercise; Muscle health; BROWN ADIPOSE-TISSUE; SKELETAL-MUSCLE; PHYSICAL-ACTIVITY; ENERGY-EXPENDITURE; DIFFERENTIATION; EXPRESSION; RESISTANCE; ENDOCRINE; FNDC5; FAT;
D O I：
10.1007/s00210-025-04083-1
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Irisin, a myokine released during physical exercise, has emerged as a key mediator of muscle health and metabolic regulation. This review synthesizes current evidence on how aerobic exercise stimulates irisin release and its subsequent effects, including enhanced muscle mass, strength, and recovery. Additionally, irisin promotes the browning of white adipose tissue, improving fat metabolism and glucose regulation. These adaptations position irisin as a promising therapeutic target for preventing metabolic disorders and optimizing exercise protocols. By exploring human studies and mechanistic insights, this review underscores irisin's potential to address global health challenges, such as obesity and type 2 diabetes, while advancing strategies for personalized exercise interventions.
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页数：29
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