Six new compounds with neuroprotective activity from the leaves of Paeonia lactiflora Pall

Twenty constituents, three new terpenes named Paeoniterpene A-C (1-3), and three new fatty glycosides named Paeoniglycoside A-C (4-6) were isolated from the leaves of Paeonia lactiflora Pall. The structures of compounds 1-6 were identified using extensive spectroscopic methods, such as NMR, MS, CD, IR, and UV. Compounds 4-6 were characterized through quantum chemical calculations and DP4+ probability analysis, and ECD definitively confirmed their structures. Additionally, all compounds were assessed for their neuroprotective effects against H2O2-induced damage in PC 12 cells. Compounds 1-3, 7, 8, 11, and 12 could significantly improve H2O2induced PC 12 injury.