Asymmetric Synthesis of the Tetracyclic Core of Venezuelaene B

被引：0

作者：

Chen, Louxi ^{[1
,2
]}

Zhang, Chao-Han ^{[1
]}

Liu, Junyang ^{[3
]}

Sun, Jianwei ^{[2
]}

Li, Chuang-Chuang ^{[1
]}

机构：

[1] Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Guangming Adv Res Inst, Dept Chem, Shenzhen 518055, Peoples R China

[2] Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong 999077, Peoples R China

[3] Wuyi Univ, Sch Pharm & Food Engn, Jiangmen 529020, Peoples R China

来源：

ORGANIC LETTERS | 2025年

基金：

国家重点研发计划; 中国国家自然科学基金;

关键词：

PAUSON-KHAND REACTION;

D O I：

10.1021/acs.orglett.5c00301

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise and efficient approach for the asymmetric synthesis of the tetracyclic core of venezuelaene B is described. Its uncommon and synthetically challenging [5-5-6-7] tetracyclic skeleton was constructed via a mild acid-promoted type I [5+2] cycloaddition, followed by a diastereoselective intramolecular Pauson-Khand reaction. The described chemistry establishes the feasibility of constructing the [5-5-6-7] tetracyclic core and several desired stereocenters (C2, C10, C11, and C14) of the final product.

引用

页数：4

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