EAACI guidelines on the management of IgE-mediated food allergy

被引：2

作者：

Santos, Alexandra F. ^{[1
,2
,3
,90
]}

Riggioni, Carmen ^{[4
,5
,6
]}

Agache, Ioana ^{[7
]}

Akdis, Cezmi A. ^{[8
]}

Akdis, Mubeccel ^{[8
]}

Alvarez-Perea, Alberto ^{[9
,10
]}

Alvaro-Lozano, Montserrat ^{[11
,12
]}

Ballmer-Weber, Barbara ^{[13
,14
]}

Barni, Simona ^{[15
]}

Beyer, Kirsten ^{[16
]}

Bindslev-Jensen, Carsten ^{[17
,18
]}

Brough, Helen A. ^{[1
,3
]}

Buyuktiryaki, Betul ^{[19
]}

Chu, Derek ^{[20
]}

Del Giacco, Stefano ^{[21
,22
]}

Dunn-Galvin, Audrey ^{[23
,24
]}

Eberlein, Bernadette ^{[25
]}

Ebisawa, Motohiro ^{[26
]}

Eigenmann, Philippe ^{[27
]}

Eiwegger, Thomas ^{[28
,29
,30
,31
]}

Feeney, Mary ^{[1
]}

Fernandez-Rivas, Montserrat ^{[32
,33
]}

Fiocchi, Alessandro ^{[34
]}

Fisher, Helen R. ^{[1
]}

Fleischer, David M. ^{[35
,36
]}

Giovannini, Mattia ^{[15
,37
]}

Gray, Claudia ^{[38
,39
,40
]}

Hoffmann-Sommergruber, Karin ^{[41
]}

Halken, Susanne ^{[42
]}

O'b Hourihane, Jonathan ^{[43
,44
]}

Jones, Christina J. ^{[45
]}

Jutel, Marek ^{[46
,47
]}

Knol, Edward F. ^{[48
,49
]}

Konstantinou, George N. ^{[50
]}

Lack, Gideon ^{[1
,2
,3
]}

Lau, Susanne ^{[16
]}

Mejias, Andreina Marques ^{[1
,3
]}

Marchisotto, Mary Jane ^{[51
,52
]}

Meyer, Rosan ^{[53
,54
]}

Mortz, Charlotte G. ^{[17
,18
]}

Moya, Beatriz ^{[55
,56
]}

Muraro, Antonella ^{[57
]}

Nilsson, Caroline ^{[58
,59
]}

de Oliveira, Lucila Camargo Lopes ^{[60
]}

O'Mahony, Liam ^{[61
]}

Papadopoulos, Nikolaos G. ^{[62
,63
]}

Perrett, Kirsten P. ^{[64
,65
,66
]}

Peters, Rachel ^{[67
,68
]}

Podesta, Marcia ^{[51
,69
]}

Poulsen, Lars K. ^{[70
]}

机构：

[1] Kings Coll London, Fac Life Sci & Med, Sch Life Course Sci, Dept Women & Childrens Hlth Pediatr Allergy, London, England

[2] Kings Coll London, Sch Immunol & Microbial Sci, Peter Gorer Dept Immunobiol, London, England

[3] Guys & St Thomas Hosp, Evelina London Childrens Hosp, Childrens Allergy Serv, London, England

[4] Hosp Sick Children, Div Immunol & Allergy, Toronto, ON, Canada

[5] SickKids Food Allergy & Anaphylaxis Program, Toronto, ON, Canada

[6] Univ Toronto, Temerty Fac Med, Dept Paediat, Toronto, ON, Canada

[7] Transylvania Univ, Fac Med, Brasov, Romania

[8] Univ Zurich, Swiss Inst Allergy & Asthma Res SIAF, Davos, Switzerland

[9] Hosp Gen Univ Gregorio Maranon, Madrid, Spain

[10] Gregorio Maranon Hlth Res Inst, Madrid, Spain

[11] Hosp St Joan Deu, Pediat Allergy & Clin Immunol Dept, Barcelona, Spain

[12] Univ Barcelona, Inst Recerca St Joan Deu, Barcelona, Spain

[13] Kantonssp St Gallen, Clin Dermatol & Allergol, St Gallen, Switzerland

[14] Univ Hosp Zurich, Dept Dermatol, Zurich, Switzerland

[15] Meyer Childrens Hosp IRCCS, Allergy Unit, Florence, Italy

[16] Charite Univ Med Berlin, Dept Pediat Resp Med Immunol & Crit Care Med, Berlin, Germany

[17] Univ Southern Denmark, Dept Dermatol, Odense, Denmark

[18] Univ Southern Denmark, Odense Univ Hosp, Allergy Ctr, Odense Res Ctr Anaphylaxis ORCA, Odense, Denmark

[19] Koc Univ, Sch Med, Dept Pediat, Div Pediat Allergy, Istanbul, Turkiye

[20] McMaster Univ, Hamilton, ON, Canada

[21] Univ Cagliari, Dept Med Sci & Publ Hlth, Cagliari, Italy

[22] Univ Cagliari, Univ Hosp Duilio Casula, Unit Allergy & Clin Immunol, Cagliari, Italy

[23] Univ Coll Cork, Infant Ctr, Dept Paediat & Child Hlth, Cork, Ireland

[24] Royal Coll Surgeons Ireland, Childrens Hlth Ireland, Paediat & Child Hlth, Dublin, Ireland

[25] Tech Univ Munich, Sch Med, Dept Dermatol & Allergy, Munich, Germany

[26] NHO Sagamihara Natl Hosp, Clin Res Ctr Allergy & Rheumatol, Sagamihara, Kanagawa, Japan

[27] Univ Hosp Geneva, Dept Pediat Gynecol & Obstet, Geneva, Switzerland

[28] Karl Landsteiner Univ Hlth Sci, Krems An Der Donau, Austria

[29] Univ Hosp St Polten, Dept Pediat & Adolescent Med, St Polten, Austria

[30] Hosp Sick Children, Res Inst, Translat Med Program, Toronto, ON, Canada

[31] Univ Toronto, Temerty Fac Med, Dept Immunol, Toronto, ON, Canada

[32] Hosp Clin San Carlos, Allergy Dept, Madrid, Spain

[33] Univ Complutense Madrid, Fac Med, IdISSC, Madrid 28040, Spain

[34] Bambino Gesu Pediat Hosp, IRCCS, Rome, Italy

[35] Univ Colorado, Sch Med, Aurora, CO USA

[36] Childrens Hosp Colorado, Aurora, CO USA

[37] Univ Florence, Dept Hlth Sci, Florence, Italy

[38] Red Cross Childrens Hosp, Cape Town, South Africa

[39] Kidsallergy Ctr, Cape Town, South Africa

[40] Univ Cape Town, Dept Paediat, Cape Town, South Africa

[41] Med Univ Vienna, Dept Pathophysiol & Allergy Res, Vienna, Austria

[42] Odense Univ Hosp, Hans Christian Andersen Childrens Hosp, Odense, Denmark

[43] Royal Coll Surgeons Ireland, Dublin, Ireland

[44] Childrens Hlth Ireland, Dublin, Ireland

[45] Univ Surrey, Fac Hlth & Med Sci, Sch Psychol, Guildford, England

[46] Wroclaw Med Univ, Fac Med, Dept Clin Immunol, Wroclaw, Poland

[47] ALL MED Med Res Inst, Wroclaw, Poland

[48] Univ Med Ctr Utrecht, Dept Ctr Translat Immunol, Utrecht, Netherlands

[49] Univ Med Ctr Utrecht, Dept Dermatol Allergol, Utrecht, Netherlands

[50] 424 Gen Mil Training Hosp, Dept Allergy & Clin Immunol, Thessaloniki, Greece

来源：

ALLERGY | 2025年 / 80卷 / 01期

关键词：

allergen immunotherapy; anaphylaxis; biologicals; diet; food allergy; IgE-mediated food allergy; management; treatment; ORAL IMMUNOTHERAPY; SUBLINGUAL IMMUNOTHERAPY; PRESCHOOL-CHILDREN; PEANUT ALLERGY; TRIAL; MILK; PREVALENCE; DISORDERS; EFFICACY; SAFETY;

D O I：

10.1111/all.16345

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

This European Academy of Allergy and Clinical Immunology (EAACI) guideline provides recommendations for the management of IgE-mediated food allergy and was developed using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) approach. Following the confirmation of IgE-mediated food allergy diagnosis, allergen avoidance and dietary advice (with support of a specialised dietitian, if possible) together with the provision of a written treatment plan, education on the recognition of allergic symptoms and prescription of medication including adrenaline using an auto-injector are essential. Patients with significant anxiety and requirement for coping strategies may benefit from support from a clinical psychologist. As immunomodulatory interventions, omalizumab is suggested for treatment of IgE-mediated food allergy in children from the age of 1 and adults; and oral allergen-specific immunotherapy is recommended for children and adolescents with peanut allergy and suggested for milk and egg allergies (generally after 4 years of age for milk and egg). Sublingual and epicutaneous immunotherapy are suggested for peanut allergy but are not yet available at the point of care. Future research into disease modifying treatments for IgE-mediated food allergy are highly needed, with standardised and patient-focused protocols and outcomes.

引用

页码：14 / 36

页数：23

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