Imaging Alpha-synuclein with Novel 5H-Imidazo[1,5-b][1,2,4]triazole Radioligands for the Diagnosis of Parkinson's Disease

被引：0
|
作者：
Song, Zhendong [1 ]
Liang, Steven H. [1 ]
机构：
[1] Emory Univ, Dept Radiol & Imaging Sci, Atlanta, GA 30322 USA
来源：
ACS MEDICINAL CHEMISTRY LETTERS | 2025年 / 16卷 / 02期
关键词：
D O I：
10.1021/acsmedchemlett.4c00607
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The invention in this patent describes novel 5H-imidazo[1,5-b][1,2,4]triazole compounds, including radiolabeled derivatives, designed to target alpha-synuclein (alpha-syn). These compounds demonstrate potential as positron emission tomography (PET) radioligands for diagnosing alpha-syn-associated brain diseases, including Parkinson's disease.
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页码：182 / 183
页数：2
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