Living Engineered Bacterial Therapeutics: Emerging Affordable Precision Interventions

被引：1
|
作者：
Srivastava, Rajkamal [1 ,2 ]
Lesser, Cammie F. [1 ,2 ,3 ,4 ]
机构：
[1] Massachusetts Gen Hosp, Ctr Bacterial Pathogenesis, Dept Med, Div Infect Dis, Boston, MA 02114 USA
[2] Harvard Med Sch, Blavatnik Inst, Dept Microbiol, Boston, MA 02115 USA
[3] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA
[4] Ragon Inst Harvard & MIT, Cambridge, MA 02139 USA
来源：
MICROBIAL BIOTECHNOLOGY | 2024年 / 17卷 / 11期
基金：
美国国家卫生研究院;
关键词：
engineered bacteria; live biotherapeutic products; smart microbes; COLI NISSLE 1917;
D O I：
10.1111/1751-7915.70057
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Live biotherapeutic products (LBPs), including engineered bacteria, are rapidly emerging as potential therapeutic interventions. These innovative therapies can serve as live in situ drug delivery platforms for the direct deposition of therapeutic payloads, including complex biologics, at sites of disease. This approach offers a platform likely to enhance therapeutic efficacy and decrease off-target side effects. LBPs also can likely be distributed at a relatively low price point, as their production can be economically scaled up. LBPs represent an exciting new means for ensuring healthy lives and promoting well-being for all ages, aligning with the World Health Organization's sustainable development goal 3.
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页数：8
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