Conservation of structural brain connectivity in people with multiple sclerosis

被引：0

作者：

Marti-Juan, Gerard ^{[1
]}

Sastre-Garriga, Jaume ^{[2
]}

Vidal-Jordana, Angela ^{[2
]}

Llufriu, Sara ^{[3
,4
,5
]}

Martinez-Heras, Eloy ^{[3
,4
,5
]}

Groppa, Sergiu ^{[6
]}

Gonzalez-Escamilla, Gabriel ^{[6
]}

Rocca, Maria A. ^{[7
,8
,9
]}

Filippi, Massimo ^{[7
,8
,9
]}

Hogestol, Einar A. ^{[10
,11
]}

Harbo, Hanne F. ^{[10
,12
]}

Foster, Michael A. ^{[13
]}

Collorone, Sara ^{[13
]}

Toosy, Ahmed T.

Schoonheim, Menno M. ^{[14
]}

Strijbis, Eva ^{[15
]}

Pontillo, Giuseppe ^{[16
]}

Petracca, Maria ^{[17
,18
]}

Deco, Gustavo ^{[19
,20
]}

Rovira, Alex ^{[1
,21
]}

Pareto, Deborah ^{[1
,21
]}

机构：

[1] Vall dHebron Res Inst VHIR, Neuroradiol Grp, Barcelona, Spain

[2] Univ Autonoma Barcelona UAB, Vall dHebron Univ Hosp, Dept Neurol Neuroimmunol, Multiple Sclerosis Ctr Catalonia Cemcat, Barcelona, Spain

[3] Hosp Clin Barcelona, Fundacio Recerca Clin Barcelona, Neuroimmunol & Multiple Sclerosis Unit, IDIBAPS, Barcelona, Spain

[4] Hosp Clin Barcelona, Fundacio Recerca Clin Barcelona, Lab Adv Imaging Neuroimmunol Dis ImaginEM, IDIBAPS, Barcelona, Spain

[5] Univ Barcelona, Barcelona, Spain

[6] Johannes Gutenberg Univ Mainz, Dept Neurol, Focus Program Translat Neurosci FTN & Immunotherap, Rhine Main Neurosci Network rmn2,Univ Med Ctr, Mainz, Germany

[7] IRCCS San Raffaele Sci Inst, Div Neurosci, Neuroimaging Res Unit, Milan, Italy

[8] IRCCS San Raffaele Sci Inst, Neurol Unit, Milan, Italy

[9] San Raffaele Univ, Vita Salute, Milan, Italy

[10] Oslo Univ Hosp, Dept Neurol, Oslo, Norway

[11] Univ Oslo, Dept Psychol, Oslo, Norway

[12] Univ Oslo, Inst Clin Med, Oslo, Norway

[13] UCL, UCL Inst Neurol, MS Ctr, Dept Neuroinflammat, Queen Sq, London, England

[14] Vrije Univ Amsterdam, MS Ctr Amsterdam, Anat & Neurosci, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands

[15] Vrije Univ Amsterdam, MS Ctr Amsterdam, Neurol, Amsterdam Neurosci,Amsterdam UMC, Amsterdam, Netherlands

[16] Univ Naples Federico II, Dept Adv Biomed Sci, Naples, Italy

[17] Univ Naples Federico II, Dept Neurosci Reprod Sci & Odontostomatol, Naples, Italy

[18] Sapienza Univ Rome, Dept Human Neurosci, Rome, Italy

[19] Univ Pompeu Fabra, Ctr Brain & Cognit, Dept Informat & Commun Technol, Computat Neurosci Grp, Barcelona, Spain

[20] Univ Pompeu Fabra, Inst Catalana Recerca & Estudis Avancats, Barcelona, Spain

[21] Univ Autonoma Barcelona, Vall dHebron Univ Hosp, Dept Radiol IDI, Barcelona, Spain

来源：

NETWORK NEUROSCIENCE | 2024年 / 8卷 / 04期

关键词：

Multiple sclerosis; Hemispheric connectivity; MRI; Structural connectivity; DIFFUSION MRI; COGNITIVE IMPAIRMENT; EFFICIENCY; NETWORKS; TRACTOGRAPHY;

D O I：

10.1162/netn_a_00404

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In our study, we investigated how multiple sclerosis (MS), a disease that affects the central nervous system, impacts brain connectivity and the conservation principle of connectivity in the brain across hemispheres. By analyzing data from 513 MS patients and 208 healthy individuals, we examined if this conservation principle holds and how it changes due to MS. Our findings revealed that both MS patients and healthy individuals exhibit a similar balance between connections within each hemisphere and between hemispheres. We also observed that as cognitive impairment and disability in MS patients increase, interhemispheric connectivity decreases while intrahemispheric connectivity compensates. This suggests that the brain attempts to maintain balance despite the disease's progression, highlighting the adaptability of neural connectivity during the course of MS.

引用

页码：1545 / 1562

页数：18

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