Circulating Extracellular Vesicles: An Effective Biomarker for Cancer Progression
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作者:
Chatterjee, Madhura
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Natl Inst Biomed Genom, Biotechnol Res & Innovat Council, Kalyani 741251, IndiaNatl Inst Biomed Genom, Biotechnol Res & Innovat Council, Kalyani 741251, India
Chatterjee, Madhura
[1
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Gupta, Saurabh
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机构:
GLA Univ, Dept Biotechnol, Mathura 281406, IndiaNatl Inst Biomed Genom, Biotechnol Res & Innovat Council, Kalyani 741251, India
Gupta, Saurabh
[2
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Nag, Sayoni
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Brainware Univ, Dept Biotechnol, Barasat 700125, IndiaNatl Inst Biomed Genom, Biotechnol Res & Innovat Council, Kalyani 741251, India
Nag, Sayoni
[3
]
Rehman, Ishita
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Neotia Univ, Dept Biotechnol, Parganas 743368, IndiaNatl Inst Biomed Genom, Biotechnol Res & Innovat Council, Kalyani 741251, India
Rehman, Ishita
[4
]
Parashar, Deepak
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Med Coll Wisconsin, Dept Med, Div Hematol Oncol, Milwaukee, WI 53226 USANatl Inst Biomed Genom, Biotechnol Res & Innovat Council, Kalyani 741251, India
Parashar, Deepak
[5
]
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Maitra, Arindam
[1
]
Das, Kaushik
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Natl Inst Biomed Genom, Biotechnol Res & Innovat Council, Kalyani 741251, IndiaNatl Inst Biomed Genom, Biotechnol Res & Innovat Council, Kalyani 741251, India
Das, Kaushik
[1
]
机构:
[1] Natl Inst Biomed Genom, Biotechnol Res & Innovat Council, Kalyani 741251, India
[2] GLA Univ, Dept Biotechnol, Mathura 281406, India
[3] Brainware Univ, Dept Biotechnol, Barasat 700125, India
[4] Neotia Univ, Dept Biotechnol, Parganas 743368, India
[5] Med Coll Wisconsin, Dept Med, Div Hematol Oncol, Milwaukee, WI 53226 USA
Extracellular vesicles (EVs), the ubiquitous part of human biology, represent a small heterogenous, membrane-enclosed body that contains a diverse payload including genetic materials in the form of DNA, RNAs, small non-coding RNAs, etc. mostly mirroring their source of origin. Since, a vast majority of research has been conducted on how nucleic acids, proteins, lipids, and metabolites, associated with EVs can be effectively utilized to identify disease progression and therapeutic responses in cancer patients, EVs are increasingly being touted as valuable and reliable identifiers of cancer biomarkers in liquid biopsies. However, the lack of comprehensive clinical validation and effective standardization protocols severely limits its applications beyond the laboratories. The present review focuses on understanding the role of circulating EVs in different cancers and how they could potentially be treated as cancer biomarkers, typically due to the presence of bioactive molecules such as small non-coding RNAs, RNAs, DNA, proteins, etc., and their utilization for fine-tuning therapies. Here, we provide a brief general biology of EVs including their classification and subsequently discuss the source of circulatory EVs, the role of their associated payload as biomarkers, and how different cancers affect the level of circulatory EVs population.
机构:
Tokyo Med Univ, Dept Mol & Cellular Med, Tokyo 1600023, Japan
Chiba Univ, Grad Sch Med, Dept Urol, Chiba 2608670, JapanTokyo Med Univ, Dept Mol & Cellular Med, Tokyo 1600023, Japan
Tamura, Takaaki
Yoshioka, Yusuke
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Tokyo Med Univ, Dept Mol & Cellular Med, Tokyo 1600023, JapanTokyo Med Univ, Dept Mol & Cellular Med, Tokyo 1600023, Japan
Yoshioka, Yusuke
Sakamoto, Shinichi
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Chiba Univ, Grad Sch Med, Dept Urol, Chiba 2608670, JapanTokyo Med Univ, Dept Mol & Cellular Med, Tokyo 1600023, Japan
Sakamoto, Shinichi
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Ichikawa, Tomohiko
Ochiya, Takahiro
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Tokyo Med Univ, Dept Mol & Cellular Med, Tokyo 1600023, JapanTokyo Med Univ, Dept Mol & Cellular Med, Tokyo 1600023, Japan
机构:
Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USA
Nagasaki Univ, Grad Sch Biomed Sci, Gastroenterol & Hepatol, Nagasaki, JapanMayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USA
Nakao, Yasuhiko
Mauer, Amy S.
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Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USAMayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USA
Mauer, Amy S.
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Amrollahi, Pouya
Parthasarathy, Gopanandan
论文数: 0引用数: 0
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Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USAMayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USA
Parthasarathy, Gopanandan
Sehrawat, Tejasav S.
论文数: 0引用数: 0
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Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USAMayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USA
Sehrawat, Tejasav S.
Vanderboom, Patrick
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Mayo Clin, Mayo Endocrine Res Unit, Rochester, MN USAMayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USA
Vanderboom, Patrick
Nair, K. Sreekumaran
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Mayo Clin, Mayo Endocrine Res Unit, Rochester, MN USAMayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USA
Nair, K. Sreekumaran
Nakao, Kazuhiko
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Nagasaki Univ, Grad Sch Biomed Sci, Gastroenterol & Hepatol, Nagasaki, JapanMayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USA
Nakao, Kazuhiko
Allen, Alina M.
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Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USAMayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USA
Allen, Alina M.
Hu, Tony Y.
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机构:
Arizona State Univ, Biodesign Inst, Virginia G Piper Biodesign Ctr Personalized Diagn, Tempe, AZ 85287 USA
Arizona State Univ, Sch Biol & Hlth Syst Engn, Tempe, AZ 85287 USAMayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USA
Hu, Tony Y.
Malhi, Harmeet
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Mayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USAMayo Clin, Div Gastroenterol & Hepatol, Rochester, MN USA
机构:
Hosp Sirio Libanes, Ctr Oncol, Sao Paulo, Brazil
Univ Fed Sa Paulo, Disciplina Hematol, Escola Paulista Med, Sao Paulo, BrazilHosp Sirio Libanes, Ctr Oncol, Sao Paulo, Brazil
Carneiro, Thiago Xavier
Marrese, Daniella Gregolin
论文数: 0引用数: 0
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机构:
Univ Fed Sa Paulo, Disciplina Hematol, Escola Paulista Med, Sao Paulo, Brazil
Grp Fleury, Sao Paulo, BrazilHosp Sirio Libanes, Ctr Oncol, Sao Paulo, Brazil
Marrese, Daniella Gregolin
Santos, Melina Goncalves dos
论文数: 0引用数: 0
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Univ Fed Sa Paulo, Disciplina Hematol, Escola Paulista Med, Sao Paulo, Brazil
Grp Fleury, Sao Paulo, BrazilHosp Sirio Libanes, Ctr Oncol, Sao Paulo, Brazil
Santos, Melina Goncalves dos
Goncalves, Matheus Vescovi
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机构:
Univ Fed Sa Paulo, Disciplina Hematol, Escola Paulista Med, Sao Paulo, Brazil
Grp Fleury, Sao Paulo, BrazilHosp Sirio Libanes, Ctr Oncol, Sao Paulo, Brazil
Goncalves, Matheus Vescovi
Novis, Yana Augusta Sarkis
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Hosp Sirio Libanes, Ctr Oncol, Sao Paulo, BrazilHosp Sirio Libanes, Ctr Oncol, Sao Paulo, Brazil
Novis, Yana Augusta Sarkis
Rizzatti, Edgar Gil
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Grp Fleury, Sao Paulo, BrazilHosp Sirio Libanes, Ctr Oncol, Sao Paulo, Brazil
Rizzatti, Edgar Gil
Rocha, Vanderson
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Hosp Sirio Libanes, Ctr Oncol, Sao Paulo, BrazilHosp Sirio Libanes, Ctr Oncol, Sao Paulo, Brazil
Rocha, Vanderson
Sandes, Alex Freire
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Grp Fleury, Sao Paulo, BrazilHosp Sirio Libanes, Ctr Oncol, Sao Paulo, Brazil
Sandes, Alex Freire
Lacerda, Marcelo Pitombeira de
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Univ Fed Sa Paulo, Disciplina Hematol, Escola Paulista Med, Sao Paulo, BrazilHosp Sirio Libanes, Ctr Oncol, Sao Paulo, Brazil
Lacerda, Marcelo Pitombeira de
Arrais-Rodrigues, Celso
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机构:
Hosp Sirio Libanes, Ctr Oncol, Sao Paulo, Brazil
Univ Fed Sa Paulo, Disciplina Hematol, Escola Paulista Med, Sao Paulo, Brazil
Grp Fleury, Sao Paulo, BrazilHosp Sirio Libanes, Ctr Oncol, Sao Paulo, Brazil
机构:
Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Dept Mol Med, Daegu 700422, South KoreaKyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Dept Mol Med, Daegu 700422, South Korea
Moon, Pyong-Gon
Lee, Jeong-Eun
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Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Dept Mol Med, Daegu 700422, South KoreaKyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Dept Mol Med, Daegu 700422, South Korea
Lee, Jeong-Eun
Cho, Young-Eun
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Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Dept Mol Med, Daegu 700422, South KoreaKyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Dept Mol Med, Daegu 700422, South Korea
Cho, Young-Eun
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Lee, Soo Jung
Jung, Jin Hyang
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机构:
Kyungpook Natl Univ Hosp, Dept Breast & Thyroid Surg, Daegu, South KoreaKyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Dept Mol Med, Daegu 700422, South Korea
Jung, Jin Hyang
Chae, Yee Soo
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Kyungpook Natl Univ Hosp, Dept Oncol Hematol, Daegu, South KoreaKyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Dept Mol Med, Daegu 700422, South Korea
Chae, Yee Soo
Bae, Han-Ik
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Kyungpook Natl Univ Hosp, Dept Pathol, Daegu, South KoreaKyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Dept Mol Med, Daegu 700422, South Korea
Bae, Han-Ik
Kim, Young-Bum
论文数: 0引用数: 0
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机构:
Beth Israel Deaconess Med Ctr, Div Endocrinol Diabet & Metab, Boston, MA 02215 USA
Harvard Univ, Sch Med, Boston, MA 02215 USAKyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Dept Mol Med, Daegu 700422, South Korea
Kim, Young-Bum
Kim, In-San
论文数: 0引用数: 0
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机构:
Kyungpook Natl Univ, Dept Biochem & Cell Biol, Sch Med, Daegu 700422, South KoreaKyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Dept Mol Med, Daegu 700422, South Korea
Kim, In-San
Park, Ho Yong
论文数: 0引用数: 0
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机构:
Kyungpook Natl Univ Hosp, Dept Breast & Thyroid Surg, Daegu, South KoreaKyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Dept Mol Med, Daegu 700422, South Korea