NF-κB pathway and angiogenesis: insights into colorectal cancer development and therapeutic targets

被引:1
|
作者
Bahrami, Ashkan [1 ]
Khalaji, Amirreza [2 ,3 ]
Najafi, Majed Bahri [4 ]
Sadati, Sina [1 ]
Raisi, Arash [1 ]
Abolhassani, Amirmohammad [1 ]
Eshraghi, Reza [1 ]
Mahabady, Mahmood Khaksary [5 ]
Rahimian, Neda [6 ,7 ,8 ]
Mirzaei, Hamed [6 ]
机构
[1] Kashan Univ Med Sci, Student Res Comm, Kashan, Iran
[2] Tabriz Univ Med Sci, Immunol Res Ctr, Tabriz, Iran
[3] Tabriz Univ Med Sci, Connect Tissue Dis Res Ctr, Tabriz, Iran
[4] Isfahan Univ Med Sci, Cardiovasc Res Inst, Appl Physiol Res Ctr, Sch Med,Dept Physiol, Esfahan, Iran
[5] Kashan Univ Med Sci, Anat Sci Res Ctr, Inst Basic Sci, Kashan, Iran
[6] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Inst Basic Sci, Kashan, Iran
[7] Iran Univ Med Sci IUMS, Inst Endocrinol & Metab, Endocrine Res Ctr, Tehran, Iran
[8] Iran Univ Med Sci, Firoozgar Hosp, Sch Med, Dept Internal Med, Tehran, Iran
关键词
Angiogenesis; Colorectal cancer; Neovascularization; NF-kappa B; VEGF; EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR ANGIOGENESIS; GENE-EXPRESSION; GROWTH; CELLS; ACTIVATION; INFLAMMATION; METASTASIS; INHIBITION; STAT3;
D O I
10.1186/s40001-024-02168-w
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Colorectal cancer (CRC) is currently ranked as the third most common type of cancer, contributing significantly to mortality and morbidity worldwide. Epigenetic and genetic changes occurred during CRC progression resulted in the cell proliferation, cancer progression, angiogenesis, and invasion. Angiogenesis is one of the crucial steps during cancer progression required for the delivery of essential nutrients to cancer cells and removes metabolic waste. During angiogenesis, different molecules are secreted from tumoral cells to trigger vascular formation including epidermal growth factor and the vascular endothelial growth factor (VEGF). The production and regulation of the secretion of these molecules are modulated by different subcellular pathways such as NF-kappa B. NF-kappa B is involved in regulation of different homeostatic pathways including apoptosis, cell proliferation, inflammation, differentiation, tumor migration, and angiogenesis. Investigation of different aspects of this pathway and its role in angiogenesis could provide a comprehensive overview about the underlying mechanisms and could be used for development of further therapeutic targets. In this review of literature, we comprehensively reviewed the current understanding and potential of NF-kappa B-related angiogenesis in CRC. Moreover, we explored the treatments that are based on the NF-kappa B pathway.
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页数:13
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