Chronic kidney disease (CKD) and cardiovascular disease (CVD) often co-exist, with notable sex-dependent differences in manifestation and progression despite both sexes sharing similar risk factors. Identifying sex-specific diagnostic markers in CKD-induced CVD could elucidate why the development and progression of these diseases differ by sex. Adult, C57BL/6J male and female mice were fed a high-adenine diet for 12 weeks to induce CKD, while control mice were given a normal diet. Adenine-treated males showed more severe CKD than females. Cardiac physiology was evaluated using electrocardiogram (ECG) and echocardiogram markers. Only adenine-treated male mice showed markers of left ventricular (LV) hypertrophy. Adenine males showed markers of LV systolic and diastolic dysfunction throughout regimen duration, worsening as the disease progressed. Adenine males had prolonged QTc interval compared to adenine females and control males. We identified a new ECG marker, Speak-J duration, which increased with disease progression and appeared earlier in adenine-treated males than in females. We identified sex-dependent differences in cardiac structure, function, and electrophysiology in a CKD-induced CVD mouse model, with adenine-treated males displaying markers of LV hypertrophy, dysfunction, and electrophysiological changes. This study demonstrates the feasibility of using this model to investigate sex-dependent cardiac differences resulting from CKD.
机构:
Prince Songkla Univ, Fac Sci, Div Hlth & Appl Sci, Hat Yai, Thailand
Prince Songkla Univ, Gut Biol & Microbiota Res Unit, Hat Yai, ThailandPrince Songkla Univ, Fac Sci, Div Hlth & Appl Sci, Hat Yai, Thailand
Hayeeawaema, Fittree
Muangnil, Paradorn
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Prince Songkla Univ, Gut Biol & Microbiota Res Unit, Hat Yai, Thailand
Prince Songkla Univ, Fac Vet Sci, Hat Yai, ThailandPrince Songkla Univ, Fac Sci, Div Hlth & Appl Sci, Hat Yai, Thailand
Muangnil, Paradorn
Jiangsakul, Julaluk
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Prince Songkla Univ, Fac Vet Sci, Hat Yai, ThailandPrince Songkla Univ, Fac Sci, Div Hlth & Appl Sci, Hat Yai, Thailand
Jiangsakul, Julaluk
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Tipbunjong, Chittipong
Huipao, Nawiya
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Prince Songkla Univ, Fac Sci, Div Hlth & Appl Sci, Hat Yai, Thailand
Prince Songkla Univ, Gut Biol & Microbiota Res Unit, Hat Yai, ThailandPrince Songkla Univ, Fac Sci, Div Hlth & Appl Sci, Hat Yai, Thailand
Huipao, Nawiya
Khuituan, Pissared
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Prince Songkla Univ, Fac Sci, Div Hlth & Appl Sci, Hat Yai, Thailand
Prince Songkla Univ, Gut Biol & Microbiota Res Unit, Hat Yai, Thailand
Prince Songkla Univ, Fac Sci, Div Hlth & Appl Sci, 15 Karnjanavanich Rd, Hat Yai 90110, ThailandPrince Songkla Univ, Fac Sci, Div Hlth & Appl Sci, Hat Yai, Thailand
机构:
Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, Hangzhou, Peoples R ChinaZhejiang Chinese Med Univ, Sch Pharmaceut Sci, Hangzhou, Peoples R China
Yang, Qiao
Su, Songya
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Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, Hangzhou, Peoples R ChinaZhejiang Chinese Med Univ, Sch Pharmaceut Sci, Hangzhou, Peoples R China
Su, Songya
Luo, Nan
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Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, Hangzhou, Peoples R ChinaZhejiang Chinese Med Univ, Sch Pharmaceut Sci, Hangzhou, Peoples R China
Luo, Nan
Cao, Gang
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Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, Hangzhou, Peoples R China
Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, 548 Binwen Rd, Hangzhou 310053, Peoples R ChinaZhejiang Chinese Med Univ, Sch Pharmaceut Sci, Hangzhou, Peoples R China
机构:
Guangzhou Univ Chinese Med, Shenzhen Tradit Chinese Med Hosp, Dept Nephrol, Shenzhen, Guangdong, Peoples R ChinaGuangzhou Univ Chinese Med, Shenzhen Tradit Chinese Med Hosp, Dept Nephrol, Shenzhen, Guangdong, Peoples R China
Liu, Xinhui
Gao, Liwen
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Guangzhou Univ Chinese Med, Clin Med Coll 4, Shenzhen, Guangdong, Peoples R ChinaGuangzhou Univ Chinese Med, Shenzhen Tradit Chinese Med Hosp, Dept Nephrol, Shenzhen, Guangdong, Peoples R China
Gao, Liwen
Huang, Xi
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Guangzhou Univ Chinese Med, Clin Med Coll 4, Shenzhen, Guangdong, Peoples R ChinaGuangzhou Univ Chinese Med, Shenzhen Tradit Chinese Med Hosp, Dept Nephrol, Shenzhen, Guangdong, Peoples R China
Huang, Xi
Deng, Ruyu
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Nanjing Univ Chinese Med, Shenzhen Tradit Chinese Med Hosp, Shenzhen, Guangdong, Peoples R ChinaGuangzhou Univ Chinese Med, Shenzhen Tradit Chinese Med Hosp, Dept Nephrol, Shenzhen, Guangdong, Peoples R China
Deng, Ruyu
Wei, Xian
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Guangzhou Univ Chinese Med, Shenzhen Tradit Chinese Med Hosp, Dept Nephrol, Shenzhen, Guangdong, Peoples R ChinaGuangzhou Univ Chinese Med, Shenzhen Tradit Chinese Med Hosp, Dept Nephrol, Shenzhen, Guangdong, Peoples R China
Wei, Xian
Lu, Jiandong
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Guangzhou Univ Chinese Med, Shenzhen Tradit Chinese Med Hosp, Dept Nephrol, Shenzhen, Guangdong, Peoples R ChinaGuangzhou Univ Chinese Med, Shenzhen Tradit Chinese Med Hosp, Dept Nephrol, Shenzhen, Guangdong, Peoples R China
Lu, Jiandong
Li, Shunmin
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Guangzhou Univ Chinese Med, Shenzhen Tradit Chinese Med Hosp, Dept Nephrol, Shenzhen, Guangdong, Peoples R ChinaGuangzhou Univ Chinese Med, Shenzhen Tradit Chinese Med Hosp, Dept Nephrol, Shenzhen, Guangdong, Peoples R China
机构:
Johns Hopkins Sch Med, Dept Pediat, Stanley Div Dev Neurovirol, Baltimore, MD 21287 USAJohns Hopkins Sch Med, Dept Pediat, Stanley Div Dev Neurovirol, Baltimore, MD 21287 USA
Xiao, J.
Kannan, G.
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Johns Hopkins Sch Med, Dept Psychiat, Div Neurobiol, Baltimore, MD 21287 USAJohns Hopkins Sch Med, Dept Pediat, Stanley Div Dev Neurovirol, Baltimore, MD 21287 USA
Kannan, G.
Jones-Brando, L.
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Johns Hopkins Sch Med, Dept Pediat, Stanley Div Dev Neurovirol, Baltimore, MD 21287 USAJohns Hopkins Sch Med, Dept Pediat, Stanley Div Dev Neurovirol, Baltimore, MD 21287 USA
Jones-Brando, L.
Brannock, C.
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NIDA, Mol Neuropsychiat Res Branch, Intramural Res Program, NIH,Dept Hlth & Humam Serv, Baltimore, MD 21224 USAJohns Hopkins Sch Med, Dept Pediat, Stanley Div Dev Neurovirol, Baltimore, MD 21287 USA
Brannock, C.
Krasnova, I. N.
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NIDA, Mol Neuropsychiat Res Branch, Intramural Res Program, NIH,Dept Hlth & Humam Serv, Baltimore, MD 21224 USAJohns Hopkins Sch Med, Dept Pediat, Stanley Div Dev Neurovirol, Baltimore, MD 21287 USA
Krasnova, I. N.
Cadet, J. L.
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NIDA, Mol Neuropsychiat Res Branch, Intramural Res Program, NIH,Dept Hlth & Humam Serv, Baltimore, MD 21224 USAJohns Hopkins Sch Med, Dept Pediat, Stanley Div Dev Neurovirol, Baltimore, MD 21287 USA
Cadet, J. L.
Pletnikov, M.
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Johns Hopkins Sch Med, Dept Psychiat, Div Neurobiol, Baltimore, MD 21287 USAJohns Hopkins Sch Med, Dept Pediat, Stanley Div Dev Neurovirol, Baltimore, MD 21287 USA
Pletnikov, M.
Yolken, R. H.
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Johns Hopkins Sch Med, Dept Pediat, Stanley Div Dev Neurovirol, Baltimore, MD 21287 USAJohns Hopkins Sch Med, Dept Pediat, Stanley Div Dev Neurovirol, Baltimore, MD 21287 USA
机构:
Zhejiang Prov Peoples Hosp, Dept Nephrol, Hangzhou, Zhejiang, Peoples R China
Hangzhou Med Coll, Peoples Hosp, Hangzhou, Zhejiang, Peoples R China
Chinese Med Nephrol Key Lab Zhejiang Prov, Hangzhou, Zhejiang, Peoples R ChinaZhejiang Prov Peoples Hosp, Dept Nephrol, Hangzhou, Zhejiang, Peoples R China
Lou, Xiaowei
Jin, Juan
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机构:
Zhejiang Prov Peoples Hosp, Dept Nephrol, Hangzhou, Zhejiang, Peoples R China
Hangzhou Med Coll, Peoples Hosp, Hangzhou, Zhejiang, Peoples R China
Chinese Med Nephrol Key Lab Zhejiang Prov, Hangzhou, Zhejiang, Peoples R ChinaZhejiang Prov Peoples Hosp, Dept Nephrol, Hangzhou, Zhejiang, Peoples R China
Jin, Juan
Gong, Jianguang
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Zhejiang Prov Peoples Hosp, Dept Nephrol, Hangzhou, Zhejiang, Peoples R China
Hangzhou Med Coll, Peoples Hosp, Hangzhou, Zhejiang, Peoples R China
Chinese Med Nephrol Key Lab Zhejiang Prov, Hangzhou, Zhejiang, Peoples R ChinaZhejiang Prov Peoples Hosp, Dept Nephrol, Hangzhou, Zhejiang, Peoples R China
Gong, Jianguang
Zhao, Li
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Zhejiang Prov Peoples Hosp, Dept Nephrol, Hangzhou, Zhejiang, Peoples R China
Hangzhou Med Coll, Peoples Hosp, Hangzhou, Zhejiang, Peoples R China
Chinese Med Nephrol Key Lab Zhejiang Prov, Hangzhou, Zhejiang, Peoples R ChinaZhejiang Prov Peoples Hosp, Dept Nephrol, Hangzhou, Zhejiang, Peoples R China
Zhao, Li
Li, Yiwen
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机构:
Zhejiang Prov Peoples Hosp, Dept Nephrol, Hangzhou, Zhejiang, Peoples R China
Hangzhou Med Coll, Peoples Hosp, Hangzhou, Zhejiang, Peoples R China
Chinese Med Nephrol Key Lab Zhejiang Prov, Hangzhou, Zhejiang, Peoples R ChinaZhejiang Prov Peoples Hosp, Dept Nephrol, Hangzhou, Zhejiang, Peoples R China
Li, Yiwen
He, Qiang
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Zhejiang Prov Peoples Hosp, Dept Nephrol, Hangzhou, Zhejiang, Peoples R China
Hangzhou Med Coll, Peoples Hosp, Hangzhou, Zhejiang, Peoples R China
Chinese Med Nephrol Key Lab Zhejiang Prov, Hangzhou, Zhejiang, Peoples R ChinaZhejiang Prov Peoples Hosp, Dept Nephrol, Hangzhou, Zhejiang, Peoples R China