Cell-cell interaction determines cell fate of mesoderm-derived cell in tongue development through Hh signaling

被引:0
|
作者
Kawasaki, Maiko [1 ]
Kawasaki, Katsushige [1 ,2 ]
Sari, Finsa Tisna [1 ]
Kudo, Takehisa [1 ,3 ]
Nihara, Jun [3 ]
Kitamura, Madoka [1 ,3 ]
Nagai, Takahiro [1 ]
Utama, Vanessa [1 ]
Ishida, Yoko [2 ]
Meguro, Fumiya [1 ]
Kesuma, Alex [1 ]
Fujita, Akira [3 ]
Nishimura, Takayuki [1 ]
Kogure, Yuan [1 ]
Maruyama, Satoshi [4 ]
Tanuma, Jun-ichi [4 ]
Kakihara, Yoshito [5 ]
Maeda, Takeyasu [2 ]
Ghafoor, Sarah [6 ]
Khonsari, Roman H. [6 ]
Corre, Pierre [7 ]
Sharpe, Paul T. [6 ]
Cobourne, Martyn [6 ]
Franco, Brunella [8 ,9 ,10 ]
Ohazama, Atsushi [1 ]
机构
[1] Niigata Univ, Grad Sch Med & Dent Sci, Div Oral Anat, Niigata, Japan
[2] Niigata Univ, Ctr Adv Oral Sci, Grad Sch Med & Dent Sci, Niigata, Japan
[3] Niigata Univ, Grad Sch Med & Dent Sci, Div Orthodont, Niigata 9518514, Japan
[4] Niigata Univ, Fac Dent, Grad Sch Med & Dent Sci, Div Oral Pathol, Niigata, Japan
[5] Niigata Univ, Fac Dent, Grad Sch Med & Dent Sci, Div Dent Pharmacol, Niigata, Japan
[6] Kings Coll London, Guys Hosp, Fac Dent Oral & Craniofacial Sci, Ctr Craniofacial & Regenerat Biol, London, England
[7] Ctr Hosp Univ Nantes, Serv Ophtalmol, 1 Pl Alexis Ricordeau, F-44000 Nantes, France
[8] Telethon Inst Genet & Med TIGEM, Naples, Italy
[9] Univ Naples Federico II, Dept Translat Med Sci, Naples, Italy
[10] Univ Naples Federico II, Sch Adv Studies, Scuola Super Meridionale, Genom & Expt Med Program, Naples, Italy
来源
ELIFE | 2024年 / 13卷
基金
日本学术振兴会;
关键词
cell differentiation; cell migration; cell-cell interaction; cranial neural crest-derived cells; X-inactivation; NEURAL CREST CELLS; INTRAFLAGELLAR TRANSPORT; ADIPOSE-TISSUE; CILIA; PALATE; GENE; ANKYLOGLOSSIA; ORIGINS; GROWTH; ROLES;
D O I
10.7554/eLife.85042
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Dysfunction of primary cilia leads to genetic disorder, ciliopathies, which shows various malformations in many vital organs such as brain. Multiple tongue deformities including cleft, hamartoma, and ankyloglossia are also seen in ciliopathies, which yield difficulties in fundamental functions such as mastication and vocalization. Here, we found these tongue anomalies in mice with mutation of ciliary protein. Abnormal cranial neural crest-derived cells (CNCC) failed to evoke Hh signal for differentiation of mesoderm-derived cells into myoblasts, which resulted in abnormal differentiation of mesoderm-derived cells into adipocytes. The ectopic adipose subsequently arrested tongue swelling formation. Ankyloglossia was caused by aberrant cell migration due to lack of non-canonical Wnt signaling. In addition to ciliopathies, these tongue anomalies are often observed as non-familial condition in human. We found that these tongue deformities could be reproduced in wild-type mice by simple mechanical manipulations to disturb cellular processes which were disrupted in mutant mice. Our results provide hints for possible future treatment in ciliopathies.
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页数:25
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