Animal models of cisplatin-induced neuropathic pain

被引：0

作者：

Li, Ningxin ^{[1
]}

Li, Mingzhu ^{[2
]}

Jin, Shengbo ^{[3
]}

Yu, Jun ^{[3
]}

Wei, Hongzhe ^{[1
]}

Wang, Wenping ^{[2
]}

Ma, Siyao ^{[2
]}

Jiang, Yuxin ^{[3
]}

Liu, Qian ^{[3
]}

Yao, Huini ^{[1
]}

机构：

[1] China Med Univ, Shenyang, Peoples R China

[2] China Med Univ, Canc Hosp, Liaoning Canc Hosp & Inst, Shenyang, Peoples R China

[3] Liaoning Univ Tradit Chinese Med, Shenyang, Peoples R China

来源：

ANIMAL MODELS AND EXPERIMENTAL MEDICINE | 2025年

基金：

中国国家自然科学基金;

关键词：

animal models; chemotherapy; cisplatin; peripheral neuropathic pain; INDUCED PERIPHERAL NEUROPATHY; MECHANICAL ALLODYNIA; GABAPENTIN;

D O I：

10.1002/ame2.12548

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cisplatin chemotherapy has been used as the main treatment for different types of cancer. However, cisplatin chemotherapy-induced peripheral neuropathic pain (CIPNP) seriously affects the treatment process and quality of life of patients. In addition, it impacts the underlying mechanism and prevention and treatment strategies, indicating that drug selection and efficacy evaluation need to be further investigated. Furthermore, an animal model that is more consistent with the pathological mechanism needs to be developed. In this study, we describe and discuss the methods of developing and detecting CIPNP models in rats and mice induced by cisplatin chemotherapy. The aim was to improve the modeling rate and develop animal models that are more consistent with the developmental pattern of the disease. In addition, the study provides ideal reference animal models for clinical research and drug discovery and development.

引用

页数：9

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