Dual targeting of DNA damage repair pathway by BET and CDK4/6 inhibitors synergistically inhibits breast cancer

被引：0
|
作者：
Chi, S. [1 ]
Wei, F. [1 ]
Fang, Y. [1 ]
Hu, Y. [1 ,2 ]
Duan, W. [1 ,2 ]
Ding, J. [1 ,2 ]
Chen, Y. [1 ,2 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China
[2] Shandong Lab Yantai Drug Discovery, Bohai Rim Adv Res Inst Drug Discovery, Yantai, Peoples R China
来源：
EUROPEAN JOURNAL OF CANCER | 2024年 / 211卷
关键词：
D O I：
10.1016/j.ejca.2024.114732
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
PB202
引用
收藏
页码：S83 / S83
页数：1
相关论文
共 50 条
  • [21] Targeting CDK4 and CDK6 in cancer
    Shom Goel
    Johann S. Bergholz
    Jean J. Zhao
    Nature Reviews Cancer, 2022, 22 : 356 - 372
  • [22] Targeting the RB-pathway in sarcoma: Utility of CDK4/6 inhibitors
    Francis, Ashleigh M.
    Carey, Jason P.
    Alexander, Angela
    Keyomarsi, Khandan
    Hunt, Kelly K.
    CANCER RESEARCH, 2014, 74 (19)
  • [23] Targeting CDK4 and CDK6 in cancer
    Goel, Shom
    Bergholz, Johann S.
    Zhao, Jean J.
    NATURE REVIEWS CANCER, 2022, 22 (06) : 356 - 372
  • [24] Targeting WEE1 Inhibits Growth of Breast Cancer Cells That Are Resistant to Endocrine Therapy and CDK4/6 Inhibitors
    Fallah, Yassi
    Demas, Diane M.
    Jin, Lu
    He, Wei
    Shajahan-Haq, Ayesha N.
    FRONTIERS IN ONCOLOGY, 2021, 11
  • [25] Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer
    Gomes, Ines
    Gallego-Paez, Lina M.
    Jimenez, Maria
    Santamaria, Patricia G.
    Mansinho, Andre
    Sousa, Rita
    Abreu, Catarina
    Suarez, Eva Gonzalez
    Costa, Luis
    Casimiro, Sandra
    CELL REPORTS MEDICINE, 2023, 4 (08)
  • [26] CDK6 overexpression promotes resistance to CDK4/6 inhibitors in breast cancer
    Li, Qing
    Razavi, Pedram
    Li, Zhiqiang
    Paula, Arnaud F. Da Cruz
    Brogi, Edi
    Scaltriti, Maurizio
    Reis-Filho, Jorge S.
    Chandarlapaty, Sarat
    CANCER RESEARCH, 2019, 79 (13)
  • [27] Therapeutic targeting of CDK4/6 inhibitor resistant breast cancer
    Lim, Elgene
    Portman, Neil
    Alexandrou, Sarah
    Haupt, Susan
    Haupt, Ygal
    Caldon, Elizabeth
    CANCER RESEARCH, 2018, 78 (04)
  • [28] IMMUNOLOGICAL MECHANISMS OF RESISTANCE TO CDK4/CDK6 INHIBITORS IN BREAST CANCER
    Petroni, Giulia
    Gouin, Kenneth
    Martinez, Aitziber Buque
    Knott, Simon
    Formenti, Silvia
    Galluzzi, Lorenzo
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 : A763 - A763
  • [29] An Update on the Clinical Use of CDK4/6 Inhibitors in Breast Cancer
    Marie Robert
    Jean-Sébastien Frenel
    Emmanuelle Bourbouloux
    Dominique Berton Rigaud
    Anne Patsouris
    Paule Augereau
    Carole Gourmelon
    Mario Campone
    Drugs, 2018, 78 : 1353 - 1362
  • [30] Position paper on CDK4/6 inhibitors in early breast cancer
    Michael Gnant
    Christian F. Singer
    Gabriel Rinnerthaler
    Georg Pfeiler
    Daniel Egle
    Marija Balic
    Rupert Bartsch
    memo - Magazine of European Medical Oncology, 2023, 16 : 135 - 144
12345