Discovery of Novel Antimalarial Agents: In vitro Biological Evaluation of a Series of Rhodanine Analogues

被引：0

作者：

Yasmin, Firdaus Suffian Farah ^{[1
]}

Priadarsshini, Senthil Kumar ^{[1
]}

Sharanya, Sritharan K. ^{[1
]}

Wan, Wong Yu ^{[1
]}

Tim, Khaw Loke ^{[2
]}

Rao, Avupati Vasudeva ^{[3
]}

机构：

[1] IMU Univ, Sch Hlth Sci, Dept Biomed Sci, Kuala Lumpur 57000, Malaysia

[2] IMU Univ, Sch Med, Dept Pathol & Pharmacol, Kuala Lumpur 57000, Malaysia

[3] IMU Univ, Sch Pharm, Dept Pharmaceut Chem, Kuala Lumpur 57000, Malaysia

来源：

RESEARCH JOURNAL OF BIOTECHNOLOGY | 2025年 / 20卷 / 01期

关键词：

Antimalarial agents; Plasmodium falciparum; Rhodanine;

D O I：

10.25303/201rjbt050054

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Discovery of novel antimalarial agents is in urgent demand due to the global emergence of Plasmodium falciparum resistant malaria against first-line drugs. In line with the demand, we studied in vitro antimalarial properties of a series of rhodanine analogues (C-C13) for their bioactive potential against P falciparum. Based on the analysis of screening results and structure-activity relationship (SAR), C11 was found to be a promising bioactive hit molecule (IC50: 4.755 mu M).

引用

页码：50 / 54

页数：5

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