Discovery of Novel Antimalarial Agents: In vitro Biological Evaluation of a Series of Rhodanine Analogues

被引：0
|
作者：
Yasmin, Firdaus Suffian Farah [1 ]
Priadarsshini, Senthil Kumar [1 ]
Sharanya, Sritharan K. [1 ]
Wan, Wong Yu [1 ]
Tim, Khaw Loke [2 ]
Rao, Avupati Vasudeva [3 ]
机构：
[1] IMU Univ, Sch Hlth Sci, Dept Biomed Sci, Kuala Lumpur 57000, Malaysia
[2] IMU Univ, Sch Med, Dept Pathol & Pharmacol, Kuala Lumpur 57000, Malaysia
[3] IMU Univ, Sch Pharm, Dept Pharmaceut Chem, Kuala Lumpur 57000, Malaysia
来源：
RESEARCH JOURNAL OF BIOTECHNOLOGY | 2025年 / 20卷 / 01期
关键词：
Antimalarial agents; Plasmodium falciparum; Rhodanine;
D O I：
10.25303/201rjbt050054
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Discovery of novel antimalarial agents is in urgent demand due to the global emergence of Plasmodium falciparum resistant malaria against first-line drugs. In line with the demand, we studied in vitro antimalarial properties of a series of rhodanine analogues (C-C13) for their bioactive potential against P falciparum. Based on the analysis of screening results and structure-activity relationship (SAR), C11 was found to be a promising bioactive hit molecule (IC50: 4.755 mu M).
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页码：50 / 54
页数：5
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