Adjuvant abemaciclib plus endocrine therapy for HR+, HER2-, high-risk early breast cancer: results from a preplanned monarchE overall survival interim analysis, including 5-year efficacy outcomes

被引:0
|
作者
Reinisch, Mattea [1 ]
Harbeck, Nadia [2 ]
Rastogi, Priya [3 ,4 ]
O'shaughnessy, Joyce [5 ]
Boyle, Frances [6 ]
Cortes, Javier [7 ,8 ]
Rugo, Hope S. [9 ]
Hamilton, Erika [10 ]
Goetz, Matthew P. [11 ]
Huang, Chiun-Sheng [12 ]
Senkus, Elzbieta [13 ]
Trakin, Alexey [14 ]
Neven, Patrick [15 ]
Huober, Jens [16 ]
Ran, Wei [17 ]
Andre, Valerie [17 ]
Munoz-Fernandez, Maria [17 ]
Antonio, Belen San [17 ]
Shahir, Ashwin [17 ]
Martin, Miguel [18 ]
Johnston, Stephen [19 ]
机构
[1] Evang Kliniken Essen Mitte, Clin Gynecol, Breast Ctr, Essen, Germany
[2] LMU Univ Hosp, Comprehens Canc Ctr Munchen, Dept Gynecol & Obstet, Breast Ctr, Munich, Germany
[3] UPMC, Hillman Canc Ctr, Pittsburgh, PA USA
[4] NSABP Fdn, Pittsburgh, PA USA
[5] Baylor Univ, Texas Oncol, US Oncol, Med Ctr, Dallas, TX USA
[6] Univ Sydney, Sydney Med Sch 4, Sydney, NSW, Australia
[7] Quironsalud Grp, Int Breast Canc Ctr IBCC 5, Barcelona, Spain
[8] Int Breast Canc Ctr IBCC, Quironsalud Grp, Barcelona, Spain
[9] Univ Calif San Francisco, Dept Med, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA USA
[10] Sarah Cannon Res Inst, Tennessee Oncol, Nashville, TN USA
[11] Mayo Clin, Rochester, MN USA
[12] Natl Taiwan Univ, Natl Taiwan Univ Hosp, Dept Surg, Coll Med, Taipei, Taiwan
[13] Med Univ Gdansk, Gdansk, Poland
[14] NN Blokhin Russian Canc Res Ctr, Moscow, Russia
[15] Univ Hosp Leuven, Multidisciplinary Breast Ctr, Louvain, Belgium
[16] Kantonsspital St Gallen, Breast Ctr, St Gallen, Switzerland
[17] Eli Lilly & Co, Indianapolis, IN USA
[18] Univ Complutense Madrid, Hosp Gen Univ Gregorio Maranon, CIBERONC, GEICAM, Madrid, Spain
[19] Royal Marsden NHS Fdn Trust, London, England
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
1085
引用
收藏
页码:227 / 228
页数:2
相关论文
共 50 条
  • [21] Cost-effectiveness analysis of abemaciclib and endocrine therapy combination for the adjuvant treatment of HR+/HER2-, node-positive, high-risk, early breast cancer
    Talwar, Ashna
    Deshmukh, Ashish
    Trivedi, Meghana
    Aparasu, Rajender R.
    CANCER RESEARCH, 2023, 83 (07)
  • [22] Abemaciclib combined with endocrine therapy as adjuvant treatment for hormone-receptor-positive, HER2-, high-risk early breast cancer: 5-year Chinese population analysis of the phase III randomized monarchE study
    Zhang, Qingyuan
    Shen, Kunwei
    Song, Chuan-gui
    Ouyang, Quchang
    Liu, Zhenzhen
    Liu, Qiang
    Feng, Jifeng
    Chiu, Joanne W. Y.
    Tang, Jinhai
    Jiang, Zefei
    Tseng, Ling-Ming
    Wang, Xiaojia
    Yang, Liu
    Qian, Chenxi
    Shao, Zhimin
    THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2024, 16
  • [23] Results from a pilot study exploring ctDNA detection using a tumor-informed assay in the monarchE trial of adjuvant abemaciclib with endocrine therapy in HR+, HER2-, node-positive, high-risk early breast cancer
    Loi, Sherene
    Johnston, Stephen
    Arteaga, Carlos
    Graff, Stephanie
    Chandarlapaty, Sarat
    Goetz, Matthew
    Desmedt, Christine
    Reis-Filho, Jorge
    Sasano, Hironobu
    Rodrik-Outmezguine, Vanessa
    Sireci, Anthony
    Rubenstein, Cynthia Sandoval
    Won, Helen
    Liu, Deli
    Litchfield, Lacey M.
    Turner, Nicholas
    CANCER RESEARCH, 2024, 84 (09)
  • [24] Cost-effectiveness of abemaciclib plus endocrine therapy in high-risk HR+/HER2–early breast cancer in China
    Qiran Wei
    YuTing Xu
    Wei Liu
    Xin Guan
    Cost Effectiveness and Resource Allocation, 21
  • [25] Cost-effectiveness of abemaciclib plus endocrine therapy in high-risk HR+/HER2-early breast cancer in China
    Wei, Qiran
    Xu, Yuting
    Liu, Wei
    Guan, Xin
    COST EFFECTIVENESS AND RESOURCE ALLOCATION, 2023, 21 (01)
  • [26] Safety outcomes from monarchE: Phase 3 study of abemaciclib combined with endocrine therapy for the adjuvant treatment of HR+, HER-2-, node-positive, high risk, early breast cancer
    Rugo, H.
    O'Shaughnessy, J.
    Song, C.
    Broom, R.
    Gumus, M.
    Yamashita, T.
    San Antonio, B.
    Shahir, A.
    Zimmermann, A.
    Zagouri, F.
    Reinisch, M.
    BREAST, 2021, 56 : S23 - S24
  • [27] Adjuvant abemaciclib combined with endocrine therapy for high-risk early breast cancer: updated efficacy and Ki-67 analysis from the monarchE study
    Fleming, G. F.
    Pagani, O.
    Regan, M. M.
    Walley, B. A.
    Francis, P. A.
    ANNALS OF ONCOLOGY, 2022, 33 (06) : 658 - 658
  • [28] Adjuvant abemaciclib combined with endocrine therapy for high-risk early breast cancer: updated efficacy and Ki-67 analysis from the monarchE study
    Harbeck, N.
    Rastogi, P.
    Martin, M.
    Tolaney, S. M.
    Shao, Z. M.
    Fasching, P. A.
    Huang, C. S.
    Jaliffe, G. G.
    Tryakin, A.
    Goetz, M. P.
    Rugo, H. S.
    Senkus, E.
    Testa, L.
    Andersson, M.
    Tamura, K.
    Del Mastro, L.
    Steger, G. G.
    Kreipe, H.
    Hegg, R.
    Sohn, J.
    Guarneri, V
    Cortes, J.
    Hamilton, E.
    Andre, V
    Wei, R.
    Barriga, S.
    Sherwood, S.
    Forrester, T.
    Munoz, M.
    Shahir, A.
    San Antonio, B.
    Nabinger, S. C.
    Toi, M.
    Johnston, S. R. D.
    O'Shaughnessy, J.
    ANNALS OF ONCOLOGY, 2021, 32 (12) : 1571 - 1581
  • [29] Adjuvant abemaciclib combined with endocrine therapy for high-risk early breast cancer: safety and patient-reported outcomes from the monarchE study
    Rugo, H. S.
    O'Shaughnessy, J.
    Boyle, F.
    Toi, M.
    Broom, R.
    Blancas, I
    Gumus, M.
    Yamashita, T.
    Im, Y-H
    Rastogi, P.
    Zagouri, F.
    Song, C.
    Campone, M.
    San Antonio, B.
    Shahir, A.
    Hulstijn, M.
    Brown, J.
    Zimmermann, A.
    Wei, R.
    Johnston, S. R. D.
    Reinisch, M.
    Tolaney, S. M.
    ANNALS OF ONCOLOGY, 2022, 33 (06) : 616 - 627
  • [30] Cost-effectiveness analysis of abemaciclib with endocrine therapy (ET) versus ET alone for HR+, HER2-, node-positive, high-risk early breast cancer in Italy
    Davie, Alison
    Traore, Sory
    Giovannitti, Massimo
    Pompilio, Giuseppe
    Lambton, Mark
    Cakar, Esra
    Chatterjee, Anuja
    GLOBAL & REGIONAL HEALTH TECHNOLOGY ASSESSMENT, 2023, 10 : 62 - 69