Bispecific T-Cell Engager Delivered through Tissue Targeting LNP Demonstrated Potent Antitumor Effects on Both Hematological Malignancies and Solid Tumors

被引:0
|
作者
Kai, Xin [1 ]
Zhang, Yixin [1 ]
Wei, Benjamin [1 ]
Tatang, Daniella [1 ]
Angus, Stu [1 ]
Jin, Caining [1 ]
Huang, Kun [1 ]
Huang, Changfeng [1 ]
Li, Haishan [1 ]
Brenner, Lou [1 ]
Xu, Qiaobing [1 ]
Zhang, Kate [1 ]
机构
[1] Hopewell Therapeut Inc, Woburn, MA USA
关键词
D O I
暂无
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
1273
引用
收藏
页码:606 / 606
页数:1
相关论文
共 42 条
  • [21] A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response
    Lameris, Roeland
    Shahine, Adam
    Pellicci, Daniel G.
    Uldrich, Adam P.
    Gras, Stephanie
    Le Nours, Jerome
    Groen, Richard W. J.
    Vree, Jana
    Reddiex, Scott J. J.
    Quinones-Parra, Sergio M.
    Richardson, Stewart K.
    Howell, Amy R.
    Zweegman, Sonja
    Godfrey, Dale I.
    de Gruijl, Tanja D.
    Rossjohn, Jamie
    van der Vliet, Hans J.
    NATURE CANCER, 2020, 1 (11) : 1054 - +
  • [22] A single-domain bispecific antibody targeting CD1d and the NKT T-cell receptor induces a potent antitumor response
    Roeland Lameris
    Adam Shahine
    Daniel G. Pellicci
    Adam P. Uldrich
    Stephanie Gras
    Jérôme Le Nours
    Richard W. J. Groen
    Jana Vree
    Scott J. J. Reddiex
    Sergio M. Quiñones-Parra
    Stewart K. Richardson
    Amy R. Howell
    Sonja Zweegman
    Dale I. Godfrey
    Tanja D. de Gruijl
    Jamie Rossjohn
    Hans J. van der Vliet
    Nature Cancer, 2020, 1 : 1054 - 1065
  • [23] Chimeric antigen-receptor T-cell therapy for hematological malignancies and solid tumors: Clinical data to date, current limitations and perspectives
    Gauthier, J.
    Yakoub-Agha, I.
    CURRENT RESEARCH IN TRANSLATIONAL MEDICINE, 2017, 65 (03) : 93 - 102
  • [24] SAIL66, a next generation CLDN6-targeting T-cell engager, demonstrates potent antitumor efficacy through dual binding to CD3/CD137
    Kamikawa, Takayuki
    Kimura, Naoki
    Ishii, Shinya
    Muraoka, Masaru
    Kodama, Tatsushi
    Taniguchi, Kenji
    Yoshimoto, Moe
    Miura-Okuda, Momoko
    Uchikawa, Ryo
    Kato, Chie
    Shinozuka, Junko
    Akai, Sho
    Naoi, Sotaro
    Tomioka, Nanami
    Nagaya, Nishiki
    Pang, Chai Ling
    Garvita, Gupta
    Feng, Shu
    Shimada, Mei
    Kamata-Sakurai, Mika
    Aburatani, Hiroyuki
    Kitazawa, Takehisa
    Igawa, Tomoyuki
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2024, 12 (10)
  • [25] CRPA1A2: A novel TCR-based T-cell engager targeting MAGEA1-positive solid tumors.
    Xie, Xingwang
    Dong, J.
    Bi, Jinglei
    Zhai, Jiahui
    Yan, Baoqi
    Li, Yonghong
    Wang, Jianghua
    Zhu, Yaping
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
  • [26] CB-839, a novel potent and selective glutaminase inhibitor, has broad antiproliferative activity in cell lines derived from both solid tumors and hematological malignancies
    Parlati, Francesco
    Demo, Susan D.
    Gross, Matthew I.
    Janes, Julie R.
    Lewis, Evan R.
    MacKinnon, Andy L.
    Rodriguez, Mirna L. M.
    Shwonek, Peter J.
    Wang, Taotao
    Yang, Jinfu
    Zhang, Dong
    Zhao, Frances
    Bennett, Mark K.
    CANCER RESEARCH, 2014, 74 (19)
  • [27] Mesothelin-targeting T cells bearing a novel T cell receptor fusion construct (TRuC) exhibit potent antitumor efficacy against solid tumors
    Ding, Jian
    Guyette, Sarah
    Schrand, Brett
    Geirut, Jessica
    Horton, Holly
    Guo, Guangwu
    Delgoffe, Greg
    Menk, Ashley
    Baeuerle, Patrick A.
    Hofmeister, Robert
    Tighe, Robert
    ONCOIMMUNOLOGY, 2023, 12 (01):
  • [28] HER2-XPAT, a novel protease-activatable T-cell engager (TCE) with potent T-cell activation and efficacy in solid tumors and large safety margins in non-human primate (NHP).
    Cattaruzza, Fiore
    Nazeer, Ayesha
    Lange, Zachary
    Koski, Caitlin
    Hammond, Mikhail
    To, Milton
    Yeung, Pete
    Lam, Sharon
    Derynck, Mika K.
    Irving, Bryan
    Schellenberger, Volker
    CANCER RESEARCH, 2021, 81 (13)
  • [29] FS118, a Bispecific Antibody Targeting LAG-3 and PD-L1, Enhances T-Cell Activation Resulting in Potent Antitumor Activity
    Kraman, Matthew
    Faroudi, Mustapha
    Allen, Natalie L.
    Kmiecik, Katarzyna
    Gliddon, Daniel
    Seal, Claire
    Koers, Alexander
    Wydro, Mateusz M.
    Batey, Sarah
    Winnewisser, Julia
    Young, Lesley
    Tuna, Mihriban
    Doody, Jacqueline
    Morrow, Michelle
    Brewis, Neil
    CLINICAL CANCER RESEARCH, 2020, 26 (13) : 3333 - 3344
  • [30] Anti-GPC3 TRAB, a first-in-class T cell-redirecting bispecific antibody targeting glypican-3 with potent in vitro and in vivo antitumor efficacy against solid tumors
    Kinoshita, Yasuko
    Ishiguro, Takahiro
    Sano, Yuji
    Azuma, Yumiko
    Tsunenari, Toshiaki
    Ono, Natsuki
    Kayukawa, Yoko
    Ueda, Otoya
    Wada, Naoko A.
    Hino, Hiroshi
    Jishage, Koichi
    Shiraiwa, Hirotake
    Kamata-Sakurai, Mika
    Nezu, Junichi
    Endo, Mika
    CANCER RESEARCH, 2016, 76