Causal relationship between childhood obesity and osteoporosis: A STROBE two-sample Mendelian randomization study

The causal relationship between childhood obesity and osteoporosis is not yet clear. Two-sample randomized Mendelian analysis was applied to examine the causal relationship between childhood obesity and osteoporosis. This study employs a two-sample Mendelian randomization (MR) approach. The single-nucleotide polymorphisms associated with childhood obesity and summary-level data for osteoporosis were selected from publicly published genome-wide association study. The childhood obesity dataset includes individuals under the age of 18 with a body mass index exceeding the 95th percentile, representing both male and female European children. The osteoporosis dataset includes individuals with osteoporosis from the European population (age 0-70), encompassing both genders. MR analysis was primarily conducted via inverse-variance weighted analysis. Quality of our study was assessed according to STROBE-MR guidelines. MR analysis revealed a statistically significant association between childhood obesity and osteoporosis via the inverse-variance weighted method (odds ratio 0.9985, 95% CI [0.9974, 0.9996], P = .0087). Other MR analysis methods also confirmed this result. The heterogeneity analysis and sensitivity analysis show the accuracy and robustness of our results. Our MR study revealed a significant causal relationship between childhood obesity and osteoporosis, indicating that childhood obesity can reduce the incidence of osteoporosis.